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Submitted by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-09-26T14:57:43Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese - Aurora Del Carmen R. Soria.pdf: 1359045 bytes, checksum: 15293f7897fb65bcb5cac643cf5347fb (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2017-09-26T14:57:55Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese - Aurora Del Carmen R. Soria.pdf: 1359045 bytes, checksum: 15293f7897fb65bcb5cac643cf5347fb (MD5) / Made available in DSpace on 2017-09-26T14:57:55Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Tese - Aurora Del Carmen R. Soria.pdf: 1359045 bytes, checksum: 15293f7897fb65bcb5cac643cf5347fb (MD5) Previous issue date: 2015-12-18 / Tuberculosis demands today great sanitary importance due to it’s high prevalence and lethality. It possesses antimicrobial resistance and hits vulnerable populational groups. The Cytomegalovirus (CMV) and the Epstein-Barr virus (EBV), after initial exposure, are capable of establishing latency in the tissues, causing modulatory effects on the immune system, allowing protection against intercurrent infections, but enabling cancer and autoimmunity in individuals with a favorable genetic backround. This work is a controlled case study aiming to verify if the viral co-infection by EBV and CMV have any influence on the onset of Tuberculosis (TB). IgG and IgM serology were carried out for EBV and CMV, also viral genome research through the Polymerase Chain Reaction technique in real time on the plasma of TB patients, and controls (subjects that had interdomiciiary contact with index cases of TB). 68 patients participated, ages ranging from 18 to 36 years and 56 paired controls. It was observed that 100% of cases and controls had positive IgG for EBV; and that 100% of cases and 96,4% of controls were IgG positive for CMV. Therefore, in that small transversal sampling the high prevalence of infection by EBV and CMV was confirmed, but not an association between the infection/latency of the viruses and the occurrence of TB. Low presence of the viral genome on the plasma was verified: 7 occurrences in the cases (10,3%) and 9 in the controls (16,1%). Despite the numerical difference, maybe highliting a tendency, there was no statistical significance. It is important that this study continues, in this way, in a longitudinal cohort of exposed individuals (home infected), with higher “n” sampling, and a smaller populational age range, that houses more prevalence of seronegatives exposed to EBV and CMV, allowing observation of the contrast with seropositives. / A tuberculose se investe na atualidade de grande importância sanitária devido a sua alta prevalência e letalidade. Possui resistência e acomete grupos populacionais vulneráveis. O citomegalovírus (CMV) e o vírus Epstein Barr (EBV), após a aquisição inicial, são capazes de estabelecer latência nos tecidos, provocando efeitos modulatórios no sistema imune, podendo proteger de infecções intercorrentes, mas favorecendo o câncer e a autoimunidade em indivíduos com o background genético favorável. O presente trabalho é um estudo de caso controle com o objetivo de verificar se a coinfecção viral pelo EBV e CMV influencia no aparecimento da Tuberculose (TB). Procedeu-se à sorologia IgG e IgM para EBV e CMV, e à pesquisa do genoma viral por meio da técnica de Reação em Cadeia da Polimerase em tempo real no plasma de pacientes com TB e controles (indivíduos que tiveram contacto intradomiciliar com casos index de tuberculose). Participaram 68 pacientes com idade entre 18 a 36 anos e 56 controles pareados. Observou-se que 100% de casos e controles eram IgG positivos para EBV; 100% de casos e 96,4% de controles eram IgG positivos para o CMV, portanto, nessa pequena amostragem transversal, confirmou-se a alta prevalência da infecção pelo EBV e CMV, mas, não se observou associação entre a infecção/latência dos vírus e a ocorrência de tuberculose. Verificou-se baixa presença do genoma viral no plasma: 7 ocorrências nos casos (10,3%) e 9 ocorrências nos controles (16,1%). Apesar da diferença numérica, talvez mostrando uma tendência, não houve significância estatística. É muito importante a continuidade do estudo, desta feita em uma coorte longitudinal de indivíduos expostos (contactantes domiciliares), com maior “n” amostral, e faixa etária populacional menor, que comporte maior prevalência de expostos soronegativos para o EBV e CMV, permitindo observar contraste com expostos seropositivos.