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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Characterization of Epstein-Barr Virus (EBV) strains in primary EBV infection

Kwok, Hin., 郭軒. January 2007 (has links)
published_or_final_version / Paediatrics and Adolescent Medicine / Master / Master of Philosophy
2

Immunological and virological correlates of persistent illness following primary Epstein-Barr virus infection

Cameron, Barbara, Medical Sciences, Faculty of Medicine, UNSW January 2005 (has links)
Primary Epstein-Barr virus (EBV) infection in childhood is typically asymptomatic, but infection later in life results in a mononucleosis with the illness severity ranging from asymptomatic to requiring hospitalisation. The illness is generally short-lived (four to six weeks following onset of symptoms), but persistent disabling symptoms (lasting up to 6 months or longer) are well described in around ten percent of individuals. The aim of this work was to characterise immunological and virological parameters in the peripheral blood, which correlate with persistence of symptoms following EBV-induced mononucleosis. Subjects were recruited prospectively following confirmed primary EBV infection, to allow blood samples and clinical data to be collected at multiple timepoints (baseline, 2 weeks, 4 weeks, 3 months and at least 12 months later). Subjects with 6 months or more of disabling symptoms were defined as ???cases??? with control subjects being those whose illness resolved within 6 weeks of enrolment. Cases were compared with control subjects in terms of: cellular EBV viral load in the peripheral blood by PCR; development of antibodies against EBV VCA (IgG and IgM) and EBNA-1 (IgG) by ELISA; proportions of peripheral blood leucocyte subsets and their activation status by flow cytometry; the magnitude, kinetics of development, and breadth of the CD8+ cytotoxic cell response by interferon-?? Elispot; cytokine levels in serum, and production by peripheral blood mononuclear cells ex vivo; and gene expression patterns in peripheral blood mononuclear cells by microarray. With the exception of gene expression, none of these parameters correlated with early resolution of symptoms or predicted clinical outcome following primary EBV infection. Antibody patterns suggest a tendency to Th2 type immune response may be associated with persistent illness. Preliminary analysis of the gene expression studies indicates that there are many genes involved in this complex disease requiring further investigation. Persistent illness following EBV infection is not associated with uncontrolled viral replication, or chronic immune activation due to an aberrant primary immune response.
3

Immunological and virological correlates of persistent illness following primary Epstein-Barr virus infection

Cameron, Barbara, Medical Sciences, Faculty of Medicine, UNSW January 2005 (has links)
Primary Epstein-Barr virus (EBV) infection in childhood is typically asymptomatic, but infection later in life results in a mononucleosis with the illness severity ranging from asymptomatic to requiring hospitalisation. The illness is generally short-lived (four to six weeks following onset of symptoms), but persistent disabling symptoms (lasting up to 6 months or longer) are well described in around ten percent of individuals. The aim of this work was to characterise immunological and virological parameters in the peripheral blood, which correlate with persistence of symptoms following EBV-induced mononucleosis. Subjects were recruited prospectively following confirmed primary EBV infection, to allow blood samples and clinical data to be collected at multiple timepoints (baseline, 2 weeks, 4 weeks, 3 months and at least 12 months later). Subjects with 6 months or more of disabling symptoms were defined as ???cases??? with control subjects being those whose illness resolved within 6 weeks of enrolment. Cases were compared with control subjects in terms of: cellular EBV viral load in the peripheral blood by PCR; development of antibodies against EBV VCA (IgG and IgM) and EBNA-1 (IgG) by ELISA; proportions of peripheral blood leucocyte subsets and their activation status by flow cytometry; the magnitude, kinetics of development, and breadth of the CD8+ cytotoxic cell response by interferon-?? Elispot; cytokine levels in serum, and production by peripheral blood mononuclear cells ex vivo; and gene expression patterns in peripheral blood mononuclear cells by microarray. With the exception of gene expression, none of these parameters correlated with early resolution of symptoms or predicted clinical outcome following primary EBV infection. Antibody patterns suggest a tendency to Th2 type immune response may be associated with persistent illness. Preliminary analysis of the gene expression studies indicates that there are many genes involved in this complex disease requiring further investigation. Persistent illness following EBV infection is not associated with uncontrolled viral replication, or chronic immune activation due to an aberrant primary immune response.
4

Characterization of Epstein-Barr Virus (EBV) strains in primary EBV infection

Kwok, Hin. January 2007 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2008. / Includes bibliographical references (leaf 102-115) Also available in print.
5

The intracellular consequences of the interaction between Epstein-barr virus protein BZLF1 and the human protein Pax5

Wakeman, Brian S. January 1900 (has links)
Thesis (M.S.)--The University of North Carolina at Greensboro, 2008. / Directed by Amy Adamson; submitted to the Dept. of Biology. Title from PDF t.p. (viewed Sep. 4, 2009). Includes bibliographical references (p. 58-61).
6

Effects of a bacterial toxin on LMP specific CTL killing of EBV transformed B cells : the effect on systemic inflammatory response and clinical outcome

Ong, Kong Wee January 2002 (has links)
No description available.
7

An investigation of patient and clinicopathological factors associated with EBV-positivity in Hodgkin's disease and the effect of EBV status on outcome

Flavell, Karen Jane January 2002 (has links)
No description available.
8

A study of the biological effect of Epstein-Barr virus encoded latent membrane protein 1 (LMP1) in human epithelial cells

黃麗敏, Wong, Lai-man. January 1999 (has links)
published_or_final_version / Biochemistry / Master / Master of Philosophy
9

Epstein-Barr virus-associated carcinoma arising outside the nasopharynx : a clinico-pathological and molecular study /

Leung, Suet-yi. January 1997 (has links)
Thesis (M.D.)--University of Hong Kong, 1998. / Includes bibliographical references (leaves 133-157).
10

A study of the biological effect of Epstein-Barr virus encoded latent membrane protein 1 (LMP1) in human epithelial cells /

Wong, Lai-man. January 1999 (has links)
Thesis (M. Phil.)--University of Hong Kong 1999. / Includes bibliographical references (leaves 102-110).

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