Made available in DSpace on 2014-12-17T14:13:36Z (GMT). No. of bitstreams: 1 MariaFRA_TESE.pdf: 3526311 bytes, checksum: d7607ac1c5b9376b616eed8c4ef9a96f (MD5) Previous issue date: 2010-06-28 / The aim of this study was to assess the acute and chronic effects of zinc in serum iron profile of children aged 6-9 years in relation to nutritional status and dietary intake. The study participants were 11 children regardless of sex, aged 6-9 years. They were selected from three public schools of the city of Natal, Brazil. Body mass index was used to assess nutritional status. In order to determine the patterns of childhood growth and ideal weight we used the standards of the World Health Organization. The dietary intake assessment was based on information from a three-day prospective food survey. The variables were energy intake, protein, lipids, carbohydrates, fiber, calcium, iron and zinc. All children underwent an intravenous administration of zinc (IVAZn) before and after oral administration of zinc (OAZn) (5 mg Zn / day) for three months. We measured serum iron, hematocrit, hemoglobin and total protein, before and after the use of oral zinc. The analysis of hematocrit, hemoglobin and total protein was performed using standard methods of clinical laboratory. Zinc levels and serum iron were measured by atomic absorption spectrophotometry. The project was evaluated and approved by the Ethics in Research Committee of Federal University of Rio Grande do Norte. Results: All children had normal weight. The consumption of energy, fat, fiber, calcium and iron were below recommended levels. However, the levels of protein and carbohydrates were high. Protein and zinc increased significantly after OAZn. Carbohydrate and protein were elevated in the blood. After OAZn, both protein and zinc increased, being statistically significant. Conclusion: The potential inhibitory effect of physiological or pharmacological doses of zinc on the profile of serum iron was observed in children with healthy weight and aged between 6 and 9 years. This negative effect of zinc did not affect the levels of hematocrit or hemoglobin, and therefore did not cause anemia. This was a multidisciplinary study, involving researchers from medicine, nutrition and pharmacy. This met the requirements of multidisciplinarity of the Post Graduate Program in Health Sciences of Federal University of Rio Grande do Norte. / O objetivo do presente estudo foi avaliar os efeitos agudos e cr?nicos de zinco no perfil de ferro s?rico de crian?as de 6 a 9 anos relacionando com o estado nutricional e a ingest?o alimentar. Os participantes deste estudo foram 11 crian?as independente do sexo, com idade de 6 a 9 anos. Elas foram selecionadas de tr?s escolas municipais da Cidade de Natal, Brasil. ?ndice de massa corporal foi utilizado para avaliar o estado nutricional. Para determinar os padr?es de crescimento infantil e para o peso ideal utilizaram-se os padr?es da Organiza??o Mundial da Sa?de. A avalia??o do consumo alimentar baseou-se nas informa??es do inqu?rito alimentar prospectivo de tr?s dias. As vari?veis estudadas foram a ingest?o de energia, prote?na, lip?dios, carboidratos, fibras, c?lcio, ferro e zinco. Todas as crian?as foram submetidas a uma administra??o venosa de zinco (AVZn), antes e ap?s a administra??o oral de zinco (AOZn) (5 mg Zn/dia) por tr?s meses. Dosaram-se ferro s?rico, hemat?crito, hemoglobina, prote?na total, antes e ap?s o uso do zinco oral. A an?lise do hemat?crito, hemoglobina e prote?nas totais foi realizada utilizando-se m?todos padronizados de laborat?rio cl?nico. Os n?veis de zinco e de ferro s?rico foram medidos por espectrofotometria de absor??o at?mica. O projeto foi avaliado e autorizado pelo Comit? de ?tica em Pesquisa da Universidade Federal do Rio Grande do Norte. Resultados: Todas as crian?as tiveram peso normal. O consumo de energia, de gorduras, de fibras, de c?lcio e de ferro estava abaixo dos n?veis recomendados. No entanto, os percentuais de prote?na e carboidratos eram elevados. Prote?na e zinco aumentaram significativamente ap?s a AOZn. Prote?na e carboidrato estavam elevados no sangue. Ap?s a AOZn, tanto a prote?na quanto o zinco aumentaram, em propor??es estatisticamente significativas. Conclus?o: O potencial efeito inibit?rio de dose fisiol?gica ou farmacol?gica de zinco sobre o perfil s?rico do ferro foi observado em crian?as com peso x 13 saud?vel e idade entre 6 e 9 anos. Esse efeito negativo do zinco n?o afetou os n?veis de hemat?crito ou hemoglobina e, consequentemente, n?o causou anemia. A realiza??o deste estudo teve car?ter multidisciplinar e envolveu pesquisadores das ?reas de medicina, nutri??o e farm?cia. Neste aspecto, preencheu os requisitos da multidisciplinaridade do Programa de P?sgradua??o em Ci?ncias da Sa?de da Universidade Federal do Rio Grande do Norte