Thesis (Ph. D.)--Columbia University, 1924. / Vita. Description based on print version record.

Thesis (Ph. D.)--Columbia University, 1926. / Vita. Description based on print version record.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1937. / Typescript. Includes abstract and vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1982. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--University of Iowa, 1924. / Biography.

Thesis (M. S.)--Civil and Environmental Engineering, Georgia Institute of Technology, 2007. / Huang, Ching-Hua, Committee Chair.

Thesis (M. Phil.)--University of Hong Kong, 2005. / Title proper from title frame. Also available in printed format.

Thesis (M.S.)--Rochester Institute of Technology, 1993. / Typescript. Includes bibliographical references: p. 90-92.

Part 1: The occurrence of bimolecular nucleophilic aromatic substitution has been established in the reaction of o-dinitrobenzene with triethyl phosphite and diethyl methylphosphonite in acetonitrile solution. There is a fine balance between the customary deoxygenation and nucleophilic substitution of aromatic nitrocompounds. The role of the o-nitro group in facilitating the nucleophilic substitution has been discussed in terms of "built-in solvation" of the reaction centres. The exclusive formation of ethyl nitrite in the reactions has been shown to be compatible with the dealkylation of a quasi-phosphonium intermediate by nitrite ions. Part 2: A series of alkyl a-hydroxyimino-p-nitrobenzyl alkylphophyl adducts have been synthesised from phosphorus-containing acids and p-nitrobenzonitrile oxide. Their solvolytic behaviour has been examined. Hydrolysis occurred in acid solution at 25°with anchimeric assistance of about 2x107 by the neighbouring oximino group, to yield the alcohol of the ester moiety. Exclusive phosphorus-oxygen fission occurred. P-Nitroaniline was formed in alkaline solution by intramolecular attack by the oximate anion, followed by a Lossen rearrangement. Evidence is presented for the intermediary of pentacovalent intermediates, and the relative reactivities of the adducts are explained by the constraints necessary for pseudo-rotation to allow further reaction to form the products in alkaline solution. The acid hydrolysis of ethyl pinacolyl methylphosphonate was shown to proceed via a unimolecular mechanism with the formation of a carbonium ion in 50% aqueous dioxin at 100 °.

First popularized in the 1970s, transition metal-catalyzed cross-couplings now constitute staple reactions for the formation of carbon-carbon and carbon-heteroatom bonds. Recent endeavours in the field have been invested towards expanding the range of compatible coupling partners, with the aim of accessing complex molecules from simple, widely available starting materials. Notably, esters represent an attractive class of alternative coupling partners compared to traditional aryl halides, due to their ubiquity and robustness. Moreover, different cleavage modes can be accessed with esters. Which bond cleavage occurs is highly dependent on which catalyst is used, providing an opportunity to quickly access diverse products from a common precursor. Chapter 1 of this thesis provides a literature overview of cross-couplings with carboxylic acid derivatives to contextualize our contributions described in Chapter 2 and 3. Chapter 2 describes the Pd-catalyzed cross-coupling of phenyl esters with alkyl boranes. Two reaction modes are enabled, namely C(acyl)–O bond activation with carbonyl-retention and C(acyl)–O bond activation with decarbonylation. As such, both alkyl ketones and alkylated arenes are accessed selectively by simple changes in the catalytic system. The disclosed reaction is applied to the diversification of bioactive molecules and discussed in light of recent mechanistic studies of related transformations. In Chapter 3, the first additive-free Ni-catalyzed amidation and transesterification of methyl esters are disclosed. In both transformations, a simple Ni catalyst enables widely available methyl or ethyl esters to be converted into value-added products, producing methanol as the only stoichiometric waste by-product. The Ni-catalyzed amidation protocol strongly contrasts wasteful yet common methods used to convert methyl esters into amides, involving wasteful hydrolysis and coupling with stoichiometric activating agents.