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Unsymmetrically substituted piperazines and ethylenediaminesChafetz, Lester, January 1955 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1955. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 82-86).
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Hydrothermal synthesis and characterization of ethylenediamine-containing molybdenum oxides/Gün, Özgül. Eanes, Mehtap January 2006 (has links) (PDF)
Thesis (Master)--İzmir Institute of Technology,İzmir, 2006 / Keywords: Hydrothermal synthesis, crystal structure, organic-inorganic hybrid materials, copper molybdate, ethylenediamine. Includes bibliographical references (leaves. 86-92).
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Equilibrium constants for the reaction of ethylenediamines with acetone and isobutyraldehyde : rate constants for the catalysis of the deduteration of isobutyraldeyde-2-ḏ by ethylenediamines /Narducy, Kenneth Wayne January 1971 (has links)
No description available.
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Some substitution reactions of cobalt (III) complexes of ethylenediaminetetraacetic acid.Cooke, Dean William January 1959 (has links)
No description available.
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Investigations of the Active Site of Microsomal Leucine Aminopeptidase by Probing with Ethylenediamine DerivativesChan, Lincoln 11 1900 (has links)
The active site of porcine microsomal aminopeptidase was probed by studying the inhibition of the enzyme using derivatives of ethylenediamine and diaminopropionic acid. In addition, some amino acids, substituted hydroxamates and phosphates were also tested. In order to synthesize diaminopropionic acid derivatives, CBZ-amino acid p-nitrophenyl esters were reduced to the corresponding aldehydes by lithium tri-t-butoxy-aluminohydride. Through the Strecker synthesis, the aldehyde intermediates were converted to diaminopropionitrile analogues which were then hydrolysed in acid to the desired products. Unfortunately, these compounds were not potent inhibitors for this enzyme. α-Amino acids were found to be better inhibitors than their β-amino counterparts and the Kᵢ of α-leucine was about 7-fold lower than its B-analogue. The amino group position of the amino acids is therefore important for enzyme recognition. On the other hand, N-alkylation of ethylenediamine was observed to abolish its inhibition potential. Furthermore, another unexpected finding in this work is that N- or 0-methylation of the hydroxamate group hinders the ability of these inhibitors to act as a bidentate zinc ligand. Although some phosphate derivatives that we tested showed poor inhibitory potency, phosphonamidate, a potential transition state analogue, might serve as a powerful inhibitor. In summary, the relationship between the structure and inhibitory potency of some inhibitors was demonstrated. / Thesis / Master of Science (MSc)
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GABA and GABA-receptors in the enteric nervous system /Ong, Jennifer. January 1985 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, Dept. of Physiology, 1986. / Includes bibliographical references (leaves 282-354).
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Organic syntheses in hydrotropic solutions: ethylenediamine and amyl alcoholBahner, Carl Tabb, January 1936 (has links)
Thesis (Ph. D.)--Columbia University, 1937. / Vita. "Literature cited": p. 44-45.
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The synthesis of some antergan analogues with unsaturated cyclohexyl and substituted aromatic ringsPark, Jung Kil January 1974 (has links)
Antergan is one of the ethylenediamine type of antihistamines;
in this work ten analogues of it were prepared. That pπ conjugation is essential to antergan's antihistaminic activity has already been established. Six of these analogues (A-l a-d, and B-l and 2, illustrated in Fig. 2 , p. 4 ) were synthesized in order that the significance of pπ conjugation in the antihistaminic properties of antergan molecule may at some future time be investigated. The problem is to find in what way alteration (i. e. , increase or decrease in) electronic density of the pπ -conjugated moiety of the molecule affects antihistaminic activity. The analogues A-l a-d involved ortho-, meta-, and para-methyl, and para-bromo substitution to the aromatic ring which gives rise to pπ conjugation in the antergan molecule; while the ring which gives rise to homo conjugation was replaced by a cyclohexyl moiety to eliminate any possible contribution of homoconjugation to antihistaminic activity. In analogue B-l, the antergan structure was modified so that the aromatic ring which gives rise to pπ, conjugation
was removed from the rest of the molecule by a methylene group, i.e. , the phenyl group was replaced by a benzyl moiety. The other ring was left unmodified. Another compound (B-2) relocated the aromatic ring giving rise to pπ conjugation to the adjacent methylene carbon, so that pπ conjugation was eliminated; this compound is the
nitrogen analogue of diphenhydramine and thiodiphenhydramine. In order that the importance of homo conjugation to antergan's antihistaminic activity may be established, the aromatic ring which gives rise to pπ, conjugation was replaced by a cyclohexyl moiety (A-3). Two compounds were synthesized in which the aromatic ring giving rise to homoconjugation were replaced by 3-cyclohexyl moieties (A-2a and b); while the aromatic ring which gives rise to pπ, conjugation was left unaltered in one of the compounds (b) and replaced by a cyclohexyl moeity in the other (a). In the tenth compound (A-1 e), both aromatic rings giving rise to both homo- and pπ - conjugation were removed and replaced by cyclohexyl moieties. The resulting analogue of antergan has already been demonstrated to have a very low antihistaminic activity compared to diphenhydramine, but it was felt that it would provide a useful comparison
for the antihistaminic activities of the other antergan analogues prepared in this work. Two final intermediates in the synthesis of other analogues of antergan were prepared. In these analogues (C-2a and b) the aromatic ring giving rise to homoconjugation would have been replaced by the 1-cyclohexenyl moiety, while the other aromatic ring which gives rise to pπ conjugation would have been the same in one of the analogues, and replaced by a cyclohexyl moiety in the other.
In intermediates of analogues D-l and 2, the ring giving rise to homoconjugation would have been replaced by 2, 5- and 1,4-cyclohexadiene respectively, while the aromatic ring giving rise to Pπ conjugation was replaced by the cyclohexyl moiety. In intermediates D-3 and 4, the aromatic ring giving rise to homoconjugation would have been replaced by cyclohexyl, while the aromatic ring giving rise to pπ, conjugation would have been replaced by 2, 6-dimethylphenyl and 3-cyclohexenyl moieties. / Pharmaceutical Sciences, Faculty of / Graduate
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Continuous EDTA titrations with direct readoutLaessig, Ronald H. January 1966 (has links)
Thesis (Ph. D.)--University of Wisconsin--Madison, 1966. / Typescript. Vita. "The appendices of the thesis consist of a collection of scientific papers (preprints and reprints) which were co-authored with my research director, Professor W.J. Blaedel." eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.
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The heats of reaction of some silver and ethylenediamine complexesJesser, Richard Alexander January 1963 (has links)
A solution calorimeter was constructed with a temperature range of one degree in the region of 25°C. The precision of the calorimeter was about 0.3%. The heats of reaction of the following silver ethylenediamine complexes were measured: Ag(en)⁺, Ag₂(en)₂⁺⁺, Ag(en)₂⁺, and AgHen⁺⁺. With the formation constants determined by Schwarzenbach (6), the respective entropies were calculated. Enthalpy and entropy data for the Ag(en)⁺, Ag₂(en)₂⁺⁺, and Ag(en) ₂⁺ complexes are reasonable. The data for the AgHen⁺⁺ complex seems anomalous. / Master of Science
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