In common with other expatriate Indian Populations, the Indian community of South Africa has a high incidence of coronary heart disease (CHD). Little information is available on the effects of exercise and diet on risk factors in this group. The present study is directed at the functional changes occurring as a result of a moderate aerobic physical activity programme, comprising 30 minutes of supervised exercise, three times per week for 15 weeks. Healthy male volunteers were recruited from the staff of the University of Durban-Westville, who were not on any lipid lowering medication and were not involved in any programme of physical activity for at least 12 weeks before the start of the project. The 41 subjects were assigned into one of three groups: exercise only (E) (15 subjects); exercise and diet (ED) (14 subjects) and a control (C) (12 subjects) group on no intervention. Besides laboratory investigations all participants were subjected to standardized fitness and anthropomorphological evaluation, a brief family history for coronary artery disease and a detailed dietary history was compiled. Baseline lipid results indicate that only 7 of the 41 subjects had normal lipid profiles using as cut-off points 5.2 mmol/l for cholesterol, 1.5 mml!l for triglyceride and 0.9 mmol/l for HDL-C. Obesity was moderately prevalent before intervention, with a mean decrease of 25% in body fat in both E and BD groups(p~0.05). The experimental subjects became leaner. After the intervention programme an average 20 percent increase was evident in physical working capacity as measured by peak V~ in both experimental groups (p~0.01). The controls showed little variation over the 15 weeks. The indices of muscular endurance and flexibility showed statistically significant changes (P~ 0.05) in both experimental groups after intervention. This certainly indicates elevated levels of fitness after the intervention. The lipid profiles show little alteration in total cholesterol, with a 7.3% decrease in triglyceride levels in the E group (which was not statistically significant) compared with a 14.7% increase in the controls. HDL-C showed an increase in both experimental groups (p~0.01). The total cholesterol to HDL-C ratio had an average fall of 11.9% in the experimental groups (P~0.05) compared with a 5.6% decrease in the control group. These data support the claim that regular, moderate exercise reduces the risk of heart disease through its effects on coronary risk factors in a high risk South African population. / Thesis (Ph.D.)-University of Durban-Westville, 1995.

Bibliography: leaves 178-210. / xiii, 230 leaves : ill. ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / This thesis examines the effects of endurance exercise training on whole body blood lactate removal, and the production and removal of blood lactate by skeletal muscle. / Thesis (Ph.D.)--University of Adelaide, Dept. of Physiology, 1997?

The Beothuk Indians were an extinct group of Amerinds who were among the earliest founders of Newfoundland. In literature, the Beothuk were described as perhaps being phenotypically more similar to Europeans than Asians (Gatschet 1890, Lloyd 1875, 1876a, Marshall 1996). In this research, mitochondrial DNA (mtDNA) analysis was performed on a Beothuk individual in order to determine his haplotype and, perhaps, shed light on the origins of the Beothuk.For this analysis, a tooth of Nonosabasut, a Beothuk chief who died in 1819 was loaned from the Royal Museum of Scotland. Ancient DNA was extracted from 172 mg of dentin from the tooth. The DNA was cut with two blunt-end restriction enzymes, RsaI and HaeIII. Double-stranded DNA adapters were ligated to the blunt ends. A single adapter was used to amplify the resulting fragments using PCR. In this manner, two libraries of the DNA were created that could be readily reamplified using a small amount of the PCR product. mtDNA type was determined by amplifying specific regions and performing Restriction Fragment Length Polymorphism analysis and sequencing. It was determined that the Beothuk individual had a 9-bp deletion at nucleotide position (np) 8272, an Alul restriction site at np 5176, and heteroplasmy for a HincII restriction site at np 13,259, indicating that the Beothuk individual falls into the Native American Haplogroup B. Haplogroup B is not present in modern Siberian populations, whereas the remaining Native American mtDNA haplogroups are. It has been hypothesized that Haplogroup B arrived in the Americas at a different time than haplogroups A, C, D, and X, about 16,000-13,000 YBP (Years Before Present) (Starikovskaya et al. 1998). Haplogroup B can be found in some modern Taiwanese, Japanese, Korean, Evenk, and other Asian populations.Sequencing of the D-Loop region revealed a G to A transition at np 16303. To our knowledge, this transition was never previously reported in a Native American. This transition has been reported in Tibetans, Koreans, Hans, and Japanese, all considered to be southeast Asian Causacoids (Torroni et al. 1993b, 1994b). This transition, also frequently described in the Caucasian Haplogroup H, is especially prevalent in Spain and among the Basque. It is described as a root haplotype of Haplogroup H whose expansion was estimated to be between 12,300-13,200 YBP (Torroni et al. 1998). This time estimate coincides with the expansion of Haplogroup B. One possible explanation for this transition may be some admixture of the Beothuk with a Caucasian population. / School of Physical Education

Thesis (M.S.)--University of Hawaii at Manoa, 2006. / Includes bibliographical references (leaves 55-58). / ix, 58 leaves, bound ill. 29 cm

[Truncated abstract] The inclusion of a warm-up in the form of prior exercise (PE) is generally advocated as a preparatory strategy of choice to improve sprint performance. Although there is evidence that both increasing muscle temperature and mobilising the cardiorespiratory system prior to exercise contribute largely to the benefit of PE on sprint performance, their relative importance is unknown. Another important question relates to situations where an athlete has to engage in a sprint shortly after one or several earlier sprints. Under these conditions, is engaging in mild exercise also the most effective preparatory strategy to adopt prior to sprinting when performed after a previous sprint(s)? It was the primary aim of this thesis to address these questions. Firstly, we hypothesised that there is a temporal shift in the mechanisms responsible for the effect of PE on power output during a maximal sprint effort, with temperature-dependent mechanisms playing a more important role at the onset of the sprint and mobilisation of the cardiorespiratory system playing a more important role later. To test this hypothesis, we compared the responses of a 30-s sprint to different PE protocols designed to control for either muscle temperature or pre-exercise VO2. ... A group of trained athletes was subjected to four consecutive bouts of 30-s sprint, each separated by 20 min of either active recovery at 40% VO2 peak or passive recovery. Our results show that PP, MP-20 and MP-10 did not fall between the first and last sprints, and were not affected by active recovery. In contrast, we found that MP10 and MP30 decrease significantly between the first and last sprint of the passive recovery trial, but not when active recovery is performed between consecutive sprints. Finally, this study also showed that the fall in mean power associated with repeated 30-s sprints in the passive recovery trial resulted primarily from a fall in early, but not late power output. These findings show that the early and late mean power output of repeated sprints respond differently to active and passive recovery, with the decrease in total mean power with repeated 30-s sprints resulting primarily from a fall in early as opposed to either late power output or peak power, thus highlighting the benefit of active recovery as a favourable preparatory strategy for the performance of repeated sprints of short (<10s) or longer duration (<30s), but not for repeated peak power.

Forty normal subjects, 19 males and 21 females, between the ages of 16 and 43 years were studied to examine the reliability of Cybex knee extension curves utilizing Segmental Curve Analysis (SCA). Each subject performed a standardized isokinetic knee extension/flexion test on the Cybex II isokinetic dynamometer. Test protocol consisted of 5 maximum repetitions at a speed of 60 deg/sec. Within one week of the initial test, each subject performed a retest. During testing, all torque and angle measurement information from the Cybex was transmitted to the SCA system. The SCA system plotted, analyzed, and quantified each torque curve for seven specific parameters. The following parameters were quantified by the SCA system: (1) torque at 20 degrees, 70 degrees, and peak torque of knee extension; (2) area of the curve to 20 degrees, 70 degrees and peak torque of knee extension; and (3) area of the torque curve between 20 and 70 degree angles of knee extension. The parameters of peak torque (r=.83 to .97; R=.98 to .99), area to 70 degree angle of knee extension (r=.76 to .87; R=.96 to .98), and area between 20 and 70 degree angles of knee extension (r=.75 to .92; R=.97 to .99) appeared to be the most reliable across trials and days, and were also found to elicit the least amount of variation for both male and female subjects. Coefficients of variation on the parameters of peak torque, area to 70, area between 20 and 70 for females ranged from 15% to 18%. For males, the coefficients of variation for peak torque, area to 70, and area between 20 and 70 ranged from 23% to 27%. Variables quantifying torque and power indices in the middle segment of torque curves appeared to be most reliable as analyzed by the SCA system. / Master of Science