Since the expatriates in management level have profound influences on the overall operation of overseas subsidiaries, it is significant for multinational corporations to understand the predictors of expatriate¡¦s entrepreneurship in cross-cultural contexts. Hence, based on 230 effective samples from expatriates in management level, this research investigates the relationships among expatriate¡¦s personality, cultural intelligence (CQ), expatriate adjustment, and international entrepreneurship, and cultural distance as a moderator. The results are outlined as follows. 1. Expatriate-oriented personality consists of high conscientiousness, agreeableness, extraversion, emotional stability (i.e., low neuroticism), and flexibility and empathy; international entrepreneurship comprises local internal initiative, external market exploitation, and venture exploration. 2. Expatriate-oriented personality has positive influences on expatriate¡¦s CQ and international entrepreneurship. 3. CQ has positive influences on expatriate adjustment and international entrepreneurship. 4. Expatriate-oriented personality has positive influences on expatriate adjustment and international entrepreneurship through the mediating effect of CQ. 5. No matter how the cultural distance is, expatriate-oriented personality is able to enhance expatriate¡¦s international entrepreneurship; in median-high cultural distance, CQ¡¦s role in international entrepreneurship achieves its maximum effectiveness; in smaller cultural distance, expatriate adjustment better promotes the performance of international entrepreneurship.