Thesis (M.S.)--Ohio University, June, 1992. / Title from PDF t.p.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1963. / Typescript. Vita. eContent provider-neutral record in process. Description based on print version record. Bibliography: leaves [115]-119.

Thesis (Ph. D.)--University of California, San Diego, 2000. / Vita. Includes bibliographical references.

Thesis (M.S.)--Texas State University--San Marcos, 2009. / Vita. Appendix: leaves 73-133 . Includes bibliographical references (leaves 68-72 ). Also available on microfilm.

Thesis (M.S.)--University of Texas at El Paso, 2009. / Title from title screen. Vita. CD-ROM. Includes bibliographical references. Also available online.

Thesis (Ph. D.)--Virginia Polytechnic Institute and State University, 1993. / Vita. Abstract. Includes bibliographical references (leaves 135-138). Also available via the Internet.

Thesis (Ph. D.)--University of Wisconsin--Madison, 1983. / Typescript. Vita. Description based on print version record. Includes bibliographical references (leaves 212-219).

Thesis (Ph. D.)--University of California, San Diego, 2006. / Title from first page of PDF file (viewed April 6, 2006). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 201-206).

Resumo: As ligas a base de níquel possuem uma composição química com elevado teor de elementos de liga, os quais são responsáveis por suas propriedades mecânicas e térmicas. Sua vasta utilização se da ao seu bom desempenho em altas temperaturas. O objetivo deste trabalho foi estudar o processo de usinagem via torneamento cilíndrico externo da liga a base de níquel Nimonic 80A, utilizando ferramentas do projeto de experimentos como a Metodologia de Taguchi e a Metodologia de Superfície de Respostas para o auxílio à resolução de problemas com múltiplas respostas em experimentos de usinagem, visando analisar qual o melhor arranjo dentre os fatores estudados, tendo como variável resposta a rugosidade superficial (Ra) e comprimento de corte (Lc). Os ensaios de usinagem foram realizados em um torno CNC, sendo considerados os seguintes parâmetros de usinagem: velocidade de corte (75 e 90 m/min), profundidade de usinagem (0,8 e 1,6 mm) e avanços (0,12 e 0,18 mm/v), pastilhas CP250 e TP2500, corpo de prova feito com material Nimonic 80A laminado a quente e Solubilizado, por fim, o fluido refrigerante variando em Mínima quantidade de Fluido (MQF) e abundante. Todo o processo foi conduzido em ciclos, em que cada ciclo terminava quando atingisse o comprimento de avanço máximo (Lf). Após cada etapa do torneamento foram realizadas as medidas do desgaste ferramental, bem como a rugosidade das peças. Pôde-se observar que o avanço apresentou maior significância com relação à rugosidade e comprimento de corte, levando a concluir que para menores valores de avanço, menores valores de rugosidades e maiores valores de comprimento de corte serão encontrados / Abstract: The nickel-based alloys have a chemical composition with high content of alloying elements, which are responsible for their mechanical and thermal properties. Its widespread use in these areas is mainly due to its performance at high temperatures. The propose of this work is to study the machining process in a cylindrical external turning in a nickel based alloy Nimonic 80A, using tools of the design of Experiments such as Taguchi Method and Response Surface Methodology for assistance to solve problems with multiple responses machining experiments aimed at analyzing what are the best setting among the factors studied with variable response to surface roughness and cutting length. The machining tests were performed on a CNC lathe, being considered the following machining parameters: cutting speed (75 and 90 m / min), depth of cut (0.8 and 1.6 mm) and feed rate (0.12 and 0.18 mm / V), TP2500 and CP250 tools, workpiece of Nimonic 80A material hot rolled and annealed and Fluid Lubricant varying amount in Minimal Quantity of Fluid (MQF) and abundant. The whole process was conducted in cycles where each cycle ended when it reached the maximum feed length (Lf). After each step of turning, were performed the measurements of the tool wear and the roughness of the parts. It can be observed that the factor feed had greater significance with respect to roughness and cutting length, leading to the conclusion that the lower were feed rate, lower values of roughness and higher values for cutting length will be found / Orientador: Messias Borges Silva / Coorientador: Marcos Valério Ribeiro / Banca: Marcela Aparecida G. Machado de Freitas / Banca: Rosinei Batista Ribeiro / Mestre

In asthma therapy, the use of theophylline to prevent bronchial spasm and glucocorticoids to decrease inflammation is widely indicated. Apart from the acute asthma attack oral theophylline is treated for chronic therapy in order to minimize inflammation and to enhance the efficiency of corticosteroids and recover steroids’ anti-inflammatory actions in COPD treatment. The preferred application route for respiratory disease treatment is by inhalation, such as dry powder inhalers (DPI) being the delivery systems of first choice. As shown recently, there is an advantageous effect if the drugs are given simultaneously which is caused by a synergistic effect at the same target cell in the lung epithelia. Therefore, it seems rational to combine both substances in one particle. This type of particle has the advantage over a combination product containing both drugs in a physical mixture which occurs rather randomly deposition leading to API segregation and non-dose-uniformity. Dry powder inhalers (DPIs) is a type of therapeutic pharmaceutical formulations usually present in the solid form. Due to the nature of the solid-state, an understanding of chemical and physical properties must be established for acquiring optimum performance of the active pharmaceutical ingredients (APIs). In recent year, generation of DPIs is a destructive procedure to meet the micron size. Such processes are inefficient and difficult to control. Moreover, according to current researches on combination APIs formulation, this type of DPIs performed a greater variability in does delivery of each active, leading to poor bioavailability and limit clinical efficient. This result suggest that combination formulations require advanced quality and functionality of particles with suitable physicochemical properties. Hence, in order to production of binary and combination DPIs products, the aim of this study was to develop the spray drying and ultrasonic process for engineering of combination drug particles that will be delivered more efficiently and independently of dose variations to the lung. Microparticles were produced by spray drying or/and ultrasonic technique. The processing parameters and addition of excipients (polymers) were optimized using a full factorial design such that microparticles were produced in a narrow size range suitable for inhalation. Employing excipients resulted in high saturation environment leading to minimized sphere particles when compared to conventional solvent. Solid state characterization of microparticles using powder x-ray diffraction and differential scanning calorimetry indicated that the particles contained crystalline but no cocrystal. The combination particles comparable to or better than micronized drug when formulated as a powder blended with lactose. It was concluded that the use of HPMC enhanced crystallinity suitable for inhalation; and combination particles improved uniform distribution on the stage of NGI.