Windows in building façade are vulnerable to blast pressures. When subjected to blast shock waves, glass windows may suffer failures, potentially causing serious injuries and casualties to the building occupants due to the flying glass shards and other projectiles. Protective films and laminated glass are widely used to protect windows against blast loads. These techniques have proven to reduce or prevent hazards associated with glass breakage. The use of steel or strengthened aluminum frames also reduce window blast hazards associated with frame failures. However, such measures are not always sufficient to mitigate the blast hazard if window retention anchors do not have sufficient resistance to blast pressures. Research on blast resistant windows is scarce in the literature. Therefore, a comprehensive research project was undertaken to address the behaviour, analysis, and design of window retention anchors. The research program consisted of combined experimental and analytical components. Three main phases were pursued, comprising of: i) Experimental research using a shock tube as blast simulator, ii) Numerical investigation based on three-dimensional finite element method (FEM) of analysis, and iii) Non-linear dynamic analysis of window systems based on a single-degree-of-freedom (SDOF) simplification. The experimental phase consisted of tests of 23 punched windows mounted on four different types of substrates consisting of structural steel, reinforced concrete, concrete block masonry, and stone masonry. The experimental parameters included window size and aspect ratio, glazing type, protective film thickness, substrate type, as well as the number and pattern of window retention anchors. Two levels of blast pressure-impulse combinations were used as per the recommendations of the U.S General Services Administration (GSA).The numerical phase involved FEM modelling and analysis of selected test windows. The FEM models were first validated against test results. The validated models were then employed to conduct an analytical parametric study. The parameters in this phase consisted of; substrate type, window frame rigidity, anchor fixity level in the substrate, window aspect ratio and size, anchor spacing, and blast pressure-impulse combination. The results demonstrated the significance of design parameters on window response, while also defining anchor force distribution along the window frame. A simplified SDOF method of analysis was developed for window systems, including the effects of anchor flexibility and substrate rigidity on non-linear response. The analysis approach includes the construction of window resistance functions in pre-break and post-break phases of response, where the latter stage of response is dominated by the membrane action of protective film. The analysis leads to the computation of anchor design forces, which have been validated against anchor shear and axial tension forces recorded experimentally. The SDOF analysis is recommended for use in designing blast-resistant window retention anchors on different substrates.