Deparment of Urban and Regional Planning / MURP / The frequency of natural disasters in informal settlements has been on the increase globally, Yet approximately 1 billion people still live in informal settlements world-wide. In South Africa, about 1.2 million people live in informal settlements characterised by inadequate infrastructure, lack of effective land use and spatial planning, high densities and are highly exposed to the risk of disasters. In general, there is a close link between informal settlements as spaces of habitation and exposure to disaster risks. Reflecting on disaster risk reduction strategies for informal settlements is therefore imperative particularly from an urban and regional planning perspective. Therefore, this work uses a case study of Hlophekane an informal settlement located in Greater Giyani Local Municipality under the Limpopo Province's Mopani District in South Africa to illustrate these concerns. The main purpose of this study is to develop disaster risk reduction strategies for Hlophekane Informal Settlement. The study sought to identify and characterize the nature of disasters in Hlophekane Informal Settlement. Data was collected from 90 households that live in Hlophekane Informal Settlement through a questionnaire survey and 3 key informant interviews were conducted. Furthermore, the study mapped disaster risk zones in Hlophekane Informal Settlement using GIS. Collected data was analysed using Statistical Package for Social Sciences (SPSS) making use of a thematic analysis and descriptive statistics. Microsoft computer software packages and Geographical Information System (GIS) were used to map disaster hotspots zones. Data was presented through the use of tables, graphs, and maps. Qualitative data was analysed making use of a range of processes and procedures to generate explanations, understanding or interpretation of the experiences of people and situations in the disaster context. The study findings in disaster risk reduction strategies are expected to provide lessons for reducing disasters in the area from an urban and regional planning perspective. Disaster Risk Reduction strategies suitable for informal settlements such as Hlophekane must be sustainable, cost effective and involve the community. A combination of the multi-sectoral and multi-displinary approaches is one of the disaster risk reduction strategies that can be implemented. This strategy integrates different sectors, government departments, NGO’s and the affected communities. Out of this strategy, several projects were identified such as in situ upgrading, roll over upgrading and complete relocation. From those projects, in situ upgrading is the most suitable, convenient and cost-effective strategy that can be implemented. / NRF