This thesis investigates the potential of express bus to serve travel demand in a polycentric region, using the Atlanta metropolitan area as a case study. Express bus, which serves as the primary mode of line-haul transit commuting for most suburbs in the Atlanta region, is primarily focused on serving traditional suburb-to-city commutes. However, more than half of the commutes in the Atlanta metro are to suburban locations. This thesis investigates the potential of an author-devised plan to enhance the transit commute to suburban employment centers, using express bus as the primary technology. Working mostly with existing routes, the plan incorporates ideas found in the literature, such as intermediate stops, transfer hubs, and local bus serving first and last mile connections. The thesis also tested existing plans, off of which the author's plan was devised. Tests were performed using the trip-based model of the Atlanta Regional Commission (ARC). Dramatic gains were seen as a result of the author-devised plan, such that 8,000 daily transit trips are added, and express bus ridership increases by 50%. Performance improved especially for routes in which intermediate stops were added. The results have implications for how transit can better serve travel demand in a polycentric region.