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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Activation of vascular smooth muscle cells

Peden, Ryan Stephen, Medical Sciences, Faculty of Medicine, UNSW January 2006 (has links)
Vascular smooth muscle cells (VSMC) in the healthy adult arterial wall are a highlydifferentiated cell type with low levels of proliferation. However, when activated these cells can undergo a phenotypic change to become proliferative, migratory and excrete higher levels of extra-cellular matrix. While this cellular change is an essential element of the adaptable vasculature, excessive proliferation of VSMC underpins the development of a number of disease states, including atherosclerosis and restenosis after balloon angioplasty. The activation of VSMC is dependent on intracellular signalling pathways broadly altering gene expression. A key feature of this process is the initial potent regulation of transcription factors such as Egr-1, c-Jun and Ets-1, which then drive further transcriptional changes resulting in phenotypic change. The aim of this thesis was to discover novel genes, particularly transcription factors, regulated early upon stimulation and to characterise their contribution to the activation of VSMC. A key stimulus for activation of VSMC is the release of fibroblast growth factor 2 (FGF-2). A microarray used to explore the effects of FGF-2 exposure demonstrated the extensive nature of transcriptional modulation. In addition, it highlighted a number of transcription factors that were not previously described in VSMC: p8, ATF-4 and SHARP-2. In particular, SHARP-2 was potently upregulated and was reconfirmed in animal models of vascular injury. The subsequent contribution these factors make to VSMC activation was also demonstrated. p8 strongly induced VSMC proliferation, while ATF-4 contributed to cytokine production and SHARP-2 potently downregulated VSMC differentiation markers. A second area that was explored related to a gene known as YRDC, which was found to be upregulated upon stimulation of VSMC. YRDC is highly conserved across almost all cellular life, however its function remains unknown. A number of novel splice variants of YRDC were discovered and demonstrated to be differentially regulated in VSMC upon stimulation. Further work to commence characterising its function showed that it interacts with key ribosomal proteins and most likely plays a role in regulating translation. The discovery of the relevance of these genes to vascular biology in addition to their transcriptional regulation makes an important contribution to increasing our understanding of the molecular mechanisms behind vascular remodelling.
22

Extracellular matrix-mediated signaling in the regulation of vascular smooth muscle cell phenotype and function /

Roy, Joy, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2001. / Härtill 5 uppsatser.
23

Design of a mechanical device for fabricating protein concentration gradients to study cell adhesion

McQuinn, Chris G. January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Chemistry. Title from title page of PDF (viewed 2008/05/14). Includes bibliographical references.
24

The role of plasmin in estrogen-mediated extracellular matrix remodeling in the rat uterus

Rogman, Alberic. January 2008 (has links)
Thesis (M.S.)--Villanova University, 2008. / Biology Dept. Includes bibliographical references.
25

Murine metapodophalangeal sesamoid bone mineralization a light and electron microscopy study

Doherty, Alison R. H. January 2007 (has links)
Thesis (M.A.)--Kent State University, 2007. / Title from PDF t.p. (viewed July 3, 2008). Advisor: William J. Landis. Includes bibliographical references (p. 64-68).
26

Extracellular matrix receptors in astrogliosis

Vincent-Héroux, Jonathan, January 1900 (has links)
Thesis (M.Sc.). / Written for the Dept. of Biology. Title from title page of PDF (viewed 2009/13/07). Includes bibliographical references.
27

Skeletal tissue proteins isolation and characterization of novel extracellular matrix proteins /

Wendel, Mikael. January 1994 (has links)
Thesis (doctoral)--Lunds Universitet, 1994. / Added t.p. with thesis statement inserted. Includes bibliographical references.
28

Pericellular matrix components and cell adhesion

Johansson, Staffan. January 1983 (has links)
Thesis (doctoral)--Uppsala University, 1983. / Includes bibliographical references (p. 29-40).
29

The role of integrin mediated cell adhesion in angiopoietin-1 and angiopoietin-2 biology /

Carlson, Timothy Ryan. January 2003 (has links)
Thesis (Ph. D.)--University of Chicago, Committee on Human Nutrition and Nutritional Biology, June 2003. / Includes bibliographical references. Also available on the Interet.
30

Skeletal tissue proteins isolation and characterization of novel extracellular matrix proteins /

Wendel, Mikael. January 1994 (has links)
Thesis (doctoral)--Lunds Universitet, 1994. / Added t.p. with thesis statement inserted. Includes bibliographical references.

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