This thesis presents for the first time a symmetrical, bilateral model of central pathways in the vestibulo-ocular reflex (VOR), based on known neural pathways and their interconnections on both sides of the brainstem. The model explains, simultaneously, the known behaviour of individual neural groups within the system (in central pathways) and of eye movements at its output. It does not require a long time constant "neural integrator" (NI) nor separate pathways for the generation of slow and fast phases of nystagmus, as in previous models. A single "neural filter" (NF, time constant < 1s) on each side of the brainstem is sufficient to provide integration in the slow phase mode, with the help of a positive feedback loop due to commissural innervation. Fast/slow phase alternation of eye movements is achieved through simple modulation of commissural inhibition by reticular burst cells. / Analytic and computer simulation studies show that the model can account, for the first time, for published response characteristics in the vestibular nuclei, and for their dependence on commissural and cerebellar pathways.

No description available.