Thesis (doctoral)--Utrecht, 1937. / Summary also in English. Bibliography: p. [93]-95.

Thesis (M.S.)--West Virginia University, 2002. / Title from document title page. Document formatted into pages; contains viii, 56 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 50-54).

Loss or partial loss of eye sight can have major effect on quality of person's life. One of the most common diseases, which causes loss or partial loss of eye sight are diabetic retinopathy and age releated macular degeneration. Both of these diseases can be prevented or mediated by early detection and proper treatment. The fundus camera, which is used to capture eye retina, has had major effect on increasing quality and speed of early detection. Images captured by fundus camera can be automatically analyzed in order to detect any possible signs of retina damage. This thesis proposes one possible way of automating this process. First part of this thesis describes eye, its diseases and capturing technology. Second part then proposes way of automating detection process and its implementation. Lastly, the results are evaluated.

The retina is the ocular tissue responsible for the detection of light. Its extensive demand for oxygen, coupled with a concomitant elevated supply, renders this tissue prone to both hypoxia and hyperoxia. In this thesis, we construct mathematical models of the retina, formulated as systems of reaction-diffusion equations, investigating its oxygen-related dynamics in healthy and diseased states. In the healthy state, we model the oxygen distribution across the human retina, examining the efficacy of the protein neuroglobin in the prevention of hypoxia. It has been suggested that neuroglobin could prevent hypoxia, either by transporting oxygen from regions where it is rich to those where it is poor, or by storing oxygen during periods of diminished supply or increased uptake. Numerical solutions demonstrate that neuroglobin may be effective in preventing or alleviating hypoxia via oxygen transport, but that its capacity for oxygen storage is essentially negligible, whilst asymptotic analysis reveals that, contrary to the prevailing assumption, neuroglobin's oxygen affinity is near optimal for oxygen transport. A further asymptotic analysis justifies the common approximation of a piecewise constant oxygen uptake across the retina, placing existing models upon a stronger theoretical foundation. In the diseased state, we explore the effect of hyperoxia upon the progression of the inherited retinal diseases, known collectively as retinitis pigmentosa. Both numerical solutions and asymptotic analyses show that this mechanism may replicate many of the patterns of retinal degeneration seen in vivo, but that others are inaccessible to it, demonstrating both the strengths and weaknesses of the oxygen toxicity hypothesis. It is shown that the wave speed of hyperoxic degeneration is negatively correlated with the local photoreceptor density, high density regions acting as a barrier to the spread of photoreceptor loss. The effects of capillary degeneration and treatment with antioxidants or trophic factors are also investigated, demonstrating that each has the potential to delay, halt or partially reverse photoreceptor loss. In addition to answering questions that are not accessible to experimental investigation, these models generate a number of experimentally testable predictions, forming the first loop in what has the potential to be a fruitful experimental/modelling cycle.

K pořízení snímků sítnice, která představuje nejdůležitější část lidského oka, je potřeba speciálního vybavení, kterým je fundus kamera. Z tohoto důvodu je cílem této práce navrhnout a implementovat systém, který bude schopný generovat takovéto snímky bez použítí této kamery. Navržený systém využívá mapování vstupního černobílého snímku krevního řečiště sítnice na barevný výstupní snímek celé sítnice. Systém se skládá ze dvou neuronových sítí: generátoru, který generuje snímky sítnic, a diskriminátoru, který klasifikuje dané snímky jako reálné či syntetické. Tento systém byl natrénován na 141 snímcích z veřejně dostupných databází. Následně byla vytvořena nová databáze obsahující více než 2,800 snímků zdravých sítnic v rozlišení 1024x1024. Tato databáze může být použita jako učební pomůcka pro oční lékaře nebo může poskytovat základ pro vývoj různých aplikací pracujících se sítnicemi.