Twenty four Jersey calves were randomly blocked according to sex and birth date, to determine the effects of supplementing Carica papaya seed (Linn) meal (CPSM) on health and growth performance of calves. In the first study, calves were fed CPSM for only 2 days to determine faecal pathogen population. In the second study; calves were randomly assigned at birth to three treatments and fed until weaning at 42 days. Each treatment had six calves. Treatments were; 1) a control group, which did not receive additive; 2) a group that was supplemented 5 g/d of Carica papaya seed meal (CPSM) and 3) the last group that was supplemented 5 g/d of a commercial product containing Lactobacillus acidophilus (Lact). After receiving milk with colostrum from their dams for 3 consecutive days after birth, calves had commercial starter pellet and fresh water ad lib. Treatments were added to whole milk from day 4 and fed to calves before being allowed to suckle from the dams for 30 min three times a day (08:00; 12:00 and 17:00). Calf starter dry matter intake (DMI) was evaluated daily while body weight (BW) and body structural growth were measured weekly. Faecal samples were collected directly from the rectum on day 7 and 10, before and after receiving CPSM respectively. The DMI; DMI/BW; BW and BWG of calves did not differ among treatments, and averaged 305.4 g/d; 7.7 g/d per BW; 39.4 kg and 32.1 kg, respectively. The initial BW, 22.2 ± 1.49 kg did not differ among groups, but the weaning BW was higher (p<0.05) for CPSM fed calves compared to control diet fed calves. It did not differ between control and Lact calves. Calves in Lact and CPSM treatments had similar average daily gain (ADG) and heart girth (HG), which were higher (p<0.05) than calves fed the control treatment. Calves fed CPSM had higher (p<0.05) hip width (HW) and shoulder height (SH) than control calves. There were effects of time (p<0.001) for starter DMI/BW, ADG and all structural body parameters, and effects (p<0.05) of interaction between time and treatments for only starter DMI/BW, ADG and HG. The CPSM treatment reduced faecal coliforms and E. coli (p<0.05) by 93.6% and 96.1%, respectively; and tended to reduce Enterobacteriaceae (p=0.056) by 96.4%. The present study revealed that feeding CPSM to calves during the pre-weaning period increased growth performance by improving average daily gain, feed efficiency and enhancing health status due to low faecal pathogen count / Agriculture, Animal Health and Human Ecology / M. Sc. (Agriculture)