El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado. / Drug counterfeiting or adulteration is a worldwide concern due to the serious consequences they generate, especially in the health and economic sectors. This concern is greater in Peru, as it is among the top five countries with drug counterfeiting incidents in the Americas, according to a study carried out in 2018 by the Pan American Health Organization. In this paper, we present our project, which aims at implementing a technological solution that provides reliable information on the origin and authenticity of these products in Peru to the drug consumer user, preserving the security and integrity of the exposed information using Blockchain technology. Likewise, it allows showing detailed drug characteristics, such as: composition, pharmaceutical form, active ingredients, among other relevant information. The technological solution, proposed by our project, aims at publishing the commercial origin of drugs from their sale in laboratories and distributors to the sale to the public in pharmacies. In the development of this paper, a bibliographic review of research on the use of blockchain technology is presented, as well as its benefits in the health sector, the architecture used by the system and the conceptual commercialization chain that supports it, and the qualitative and quantitative validation for the drug query service is shown. / Revisión por pares

Malaria is still an epidemic in many parts of the world-about 220 million people are still infected with malaria worldwide and about 700 thousand people die from this disease per year. Most of the drugs used to treat malaria work well if they are used as required and they contain the right amounts of the active ingredient; however, it is estimated that more than 10% of drugs traded worldwide are counterfeits including 38% to 53% of antimalarial tablets produced in China and India. Due to the lack of data covering the extent of counterfeit antimalarial drugs in Ghana, the purpose of this quantitative study was to determine the percentage of counterfeit antimalarial drugs sold in Ghana by assessing the amounts of the 2 most common antimalarial drugs, artemether (ATMT) and lumefantrine (LMFT) in drugs sold in Ghana retail outlets. These drugs were purchased from retail outlets in Ghana and analyses at the Mayo Clinic Pharmacology core lab (Rochester, MN). The quality of the drugs were characterized by comparing the actual amount of ATMT & LMFT in each tablet to the expected amount. Using explanatory theory along with dose response-response occupancy theory, the researcher addressed quantitative solutions to questions related to the percentage and distribution of counterfeit ATMT and LMFT tablets. The results revealed that overall 20% of the drugs are counterfeit; this is not dependent on the location or kind of outlet but rather depends on whether the tablets were imported or locally manufactured and whether the tablets had a pedigree scratch panel. This study provides a better understanding of how much antimalarial medication is counterfeit in Ghana, which will aid interventions to minimize the adverse effects of counterfeit antimalarial medication in Ghana