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Synthese der natürlichen tRNA Nukleosidmodifikationen Queuosin und ArchaeosinKlepper, Florian 05 March 2007 (has links) (PDF)
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Decoy gelatin nanoparticles as a novel tool to elucidate the role of NF-kB in Kupffer cells on hepatic ischemia/reperfusion injuryHoffmann, Florian 26 June 2007 (has links) (PDF)
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Entwicklung eines Baukastensystems zum Design molekularer MagneteKaps, Eike 19 June 2007 (has links) (PDF)
No description available.
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Optimierung des Adeno-assoziierten Virus Vektorsystems für die in vivo AnwendungGerner, Franz 06 July 2007 (has links) (PDF)
No description available.
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The role of Src-homology 2 domain containing tyrosine phosphatase 2 in growth factor dependent endothelial signalling and angiogenesisMannell, Hanna 24 May 2007 (has links) (PDF)
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Loss of the SNARE protein Sec22p selectively represses caesium accumulation in yeast and plantsDräxl, Stephan Johann 14 December 2012 (has links) (PDF)
The rare alkali ion caesium (Cs+) is assimilated by eukaryotes, even though it is not an
essential nutrient. It poses an environmental concern through the anthropogenic release of
its radioisotopes, 134Cs and 137Cs. Bioavailability and long half-lives favour its uptake and
accumulation in plants, via which radiocaesium can be introduced to the food chain. Cs+ ions
are taken up via potassium-(K+)-related pathways due to the biophysical similarity of these
cations. This makes it difficult to solely manipulate Cs+ accumulation in plants without
disturbing the homeostasis of essential ions at the same time.
This work shows that the soluble N-ethylmaleimide sensitive factor attachment receptor
(SNARE) Sec22p, previously described as a member of the protein sorting machinery,
specifically affects Cs+ accumulation in yeast by regulating the selectivity of vacuolar
deposition. A similar phenotype became apparent for a homologous plant protein, SEC22.
The loss of Saccharomyces cerevisiae Sec22p reduces Cs+ uptake by more than half, while
at the same time leaving essential cations undisturbed. Mathematical modelling of wild-type
and mutant Cs+ uptake kinetics proposes that sec22Δ is defective in vacuolar
compartmentalisation of Cs+, which is proven by biochemical fractionation. Morphological
alterations were not produced by the loss of Sec22p, only a Cs+-dependent vacuolar
fragmentation can be observed. These results indicate a so far undescribed function of
Sec22p in assuring a non-selective ion deposition to the vacuole, which is necessary in ion
detoxification, while its loss induces discrimination against vacuolar Cs+ deposition. A
developmentally controlled loss-of-function mutant of the orthologous gene SEC22
(At1g11890) in A. thaliana displays a similar phenotype, having specifically reduced Cs+
enrichment without detrimental growth defects, thereby translating the yeast findings to a
multicellular context. Furthermore, a functional complementation of the yeast mutant Cs+
phenotype by the plant gene transcript was possible. Selective reduction of Cs+ accumulation
in plants by loss of a single gene product represents a new route to limit radiocaesium input
to the food chain without disturbing basic plant nutrition and growth.
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New analytical methods for the assessment of the physical stability of therapeutical proteinsSpalthoff, Veronika Maria 07 February 2013 (has links) (PDF)
No description available.
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Identification and characterization of novel candidate molecules for posttraumatic stress disorderHerrmann, Leonie 31 October 2012 (has links) (PDF)
No description available.
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Tailor-Made highly nucleophilic pyridines for organocatalysisTandon, Raman 24 April 2013 (has links) (PDF)
No description available.
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Untersuchungen zur katalytischen Ethylenepoxidierung über Silber - Überbrückung des pressure gap-ProblemsBöcklein, Sebastian 18 April 2013 (has links) (PDF)
No description available.
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