There are insufficient randomized controlled trials to address whether screening for type 2 diabetes mellitus (T2DM) improves health outcomes. This systematic review sought to cast a wider net and synthesise evidence from non-randomised intervention studies to assess the effectiveness of T2DM screening in adults for reducing mortality and T2DM-associated morbidity. We searched PubMed/MEDLINE, Scopus, Web of Science, CINAHL, Academic Search Premier and Health Source Nursing Academic (inception onwards; last search July 2021). We included non-randomised intervention studies that assessed T2DM screening compared to no screening, in adults without known T2DM. Screening was performed independently by two reviewers. Data was abstracted by one reviewer and checked by a second, as was risk of bias (ROBINS-I) and certainty of evidence (GRADE). A narrative summary was performed. We screened 10,892 records, retrieving 67 for full-text screening with one record meeting inclusion criteria. The study was a prospective cohort comparing T2DM screening versus no screening. It included adults, 40 - 65 years, with no known T2DM from a single community practice in Ely, England (N = 4,936) and evaluated outcomes at two time periods. The study was assessed as having moderate risk of bias. There may be little or no difference in mortality between those who were invited to screening versus those who were not invited (1990-1999: adjusted hazard ratio (aHR) 0.79 [95% confidence interval (CI) 0.63 – 1.00], n = 4,936, low certainty evidence and 2000 - 2008: aHR 1.18 [95% CI 0.93 - 1.51], n = 3,002, low certainty evidence). We found only one study reporting the effectiveness of screening for T2DM in adults. Therefore, despite ongoing T2DM screening in clinical care, this review highlights an important research gap in understanding the true health benefits of screening.

Background: HIV incidence amongst adolescents in Southern Africa remains extremely high. The importance of adolescent HIV prevention strategies in tackling the epidemic worldwide is increasingly recognised with a global target from UNICEF to reduce new adolescent HIV infections by 75% by 2020. Adolescent vulnerability to HIV infection is a result of a complex interplay between structural, economic, socio-cultural, and biological factors during a phase when behaviours associated with HIV acquisition and sexual and reproductive health-seeking are initiated. The vulnerability of young people to HIV is particularly manifest in South Africa, where young women aged 15-24 accounted for almost 40% of new HIV infections in 2017. PreExposure Prophylaxis (PrEP) has been demonstrated to be effective for preventing HIV infection in adults but there is little data on its implementation among young people. Given the HIV incidence rates amongst adolescents in Southern Africa, oral PrEP for this group is likely to have an impact on population-level HIV incidence. We designed an open-label demonstration study known as Pluspills, for adolescents aged 15-19 years in South Africa to understand the safety, feasibility, and patterns of use of oral pre-exposure prophylaxis (PrEP) as part of a broad package of interventions, to prevent HIV. Methods: Pluspills was conducted in two distinct peri-urban settings in Johannesburg and Cape Town. The aim was to study the safety and acceptability of oral PrEP (tenofovir disoproxil fumarate/Emtricitabine) in two adolescent populations in South Africa. HIV-negative participants between 15-19 years old participated in an open-label oral PrEP study over 52 weeks. Participants took daily PrEP for the first 12 weeks and were then given the choice to opt-in or opt-out of PrEP use at three-monthly intervals. Serial plasma and DBS tenofovir concentrations were measured at every PrEP refill visit, and results were discussed with participants during adherence counselling sessions. Testing for sexually transmitted infections (STI's) was conducted at baseline, twelve and forty-eight weeks. Findings: Overall 148 participants were enrolled (median age 18 years; 67% female) and initiated PrEP. STI prevalence at the study start was high at 41% (60/148) and remained high throughout the study. The decision to stop using PrEP was made by 26 (18%) participants at 6 the 12-week visit. Cumulative PrEP opt-out at weeks 24 and 36 comprised 41% (60/148) and 43% (63/148) of the total cohort respectively. PrEP was relatively well tolerated with few reported adverse events. Tenofovir diphosphate (TFV-DP) levels as measured in dried blood spot samples were detectable (>16fmol/punch) in 92% (108/118)) of participants who reported PrEP use at week 12, 74% at week 24 (74/100), and 58% (22/37) by the end of the study. One HIV seroconversion occurred during the study (0.76/100 person-years) in a 19-yearold female participant who had chosen to stop taking PrEP, 24 weeks before diagnosis. Interpretation: In this small cohort of South African adolescents at risk of HIV acquisition, PrEP was safe and well-tolerated in those who continued to use it. PrEP use decreased throughout the study as visit frequency declined. The incidence of sexually transmitted infections remained high, despite low HIV incidence. The study confirms that this population needs access to PrEP with particular attention to tailored adherence support. Young people would also possibly benefit from the option for more frequent and flexible visit schedules.

Background: It's been 20 years since the Western Cape (WC) province of South Africa launched its first Prevention of Mother-To-Child-Transmission of HIV(PMTCT) pilot programme in Khayelitsha. The programme evolved alongside the World Health Organization (WHO) guidelines; in 2013 the recommended guidelines in the province was WHO Option B+( life-long antiretroviral therapy (ART) irrespective of CD4 count, and exclusive breastfeeding for the first 6 months of life). Alongside the explanation of the PMTCT programme, the province gradually implemented patient administrative systems in all fixed public health facilities; these systems all shared a unique patient identifier called the folder number. The digitization of folder number lead to the establishment of the Provincial Health Data Centre (PHDC), an African health information exchange (HIE) developed and hosted in the WC Department of Health. The HIE also integrated data from disease management information systems (Three Interlinked Electronic Registers (TIER) and the Electronic Tuberculosis Register (ETR)), allowing the ability to track the cohort of pregnant women living with HIV who attend public health services across the Western Cape. Here we report the latest analysis of vertical HIV transmission in the era of WHO Option B+ with the advantage of a maturing consolidated African HIE. The primary aim of the study was to describe coverage of the PMTCT care cascade, including the implementation of maternal viral load monitoring and early infant diagnosis, among HIV positive women who presented antenatal care, or delivered in the absence of antenatal care, at a public health facility in Khayelitsha subdistrict in 2017; and to quantify MTCT risk factors and outcomes among this cohort up to 12 months post-partum. Methods: Patient-level consolidated PHDC data were used to draw an observational cohort consisting of all live-born and linked mother-infant pairs in which the mother was HIV positive, at any point prior to her first antenatal visit up to 12 months post-partum and attended antenatal care, or in the absence of antenatal care delivered in Khayelitsha in 2017. The PHDC provided a single summative record per pregnancy for each woman (linked to her infant after birth) which enabled the assessment of PMTCT uptake from her first antenatal visit through delivery to infant early infant diagnosis (EID) of HIV-PCR testing and PHDC ascertainment of HIV up to the end of the index period (i.e. 12 months post-partum). iii Using this cohort of HIV-exposed infants, a protocol was designed (Section A: Protocol) to assess the outcomes of the implementation of WHO Option B+(lifelong ART for all HIV positive pregnant women; and periodic re-testing of HIV negative women) under the latest EID guidelines of routine birth HIV-PCR (within 1 week of birth), and repeat testing at 10 weeks (between 2 and 14 weeks of birth) or a first HIV-test at 10 weeks if the infant had not been tested at birth. Continuous variables were converted to categorical variables according to pre-set thresholds, all categorical variables were described using proportions, and frequency tables were used for comparison. Timing of ART initiation was categorized as a binary variable which was assigned 1 if the mother started ART before the first antenatal visits, and 0 of she started ART at the first antenatal visit or anytime during the pregnancy. Viral load was categorised according to coverage and suppression status; virologic suppression was defined as having a viral load of 1000 copies/ml or less after 3 months on ART. Analysis was performed in using R studio; descriptive statistics were used to assess coverage along the PMTCT care cascade, and logistic regression was run to quantify a priori defined risk factors associated with MTCT. Results: The study cohort of 2 576 mother-infant pairs (2548 women living with HIV (WLHIV)) presented in the manuscript was a young cohort with a median age of 30 years (interquartile range of 26 – 34), in which most women delivered vaginally (70.5%), and 78.3% attended at least one antenatal visit before delivery. Most WLHIV (88.3%) presented to their first pregnancy related visit (antenatal care or delivery) already knowing their status, of whom 77.9% were already on ART. 94.5% of women diagnosed prior to birth were initiated on ART prior; 85.0% of these women received a viral load test antenatally, of whom 88.0% were virologically suppressed. Early infant diagnosis coverage was sub-optimal with birth HIV-PCR (within 7 days of birth) coverage of 79.21% among HIV exposed infants (HEI); an even lower proportion (57.9%) of HEI who tested negative at birth had a repeat test around 10-weeks. HIV-PCR ascertained MTCT was 0.8% at 10 weeks, consolidated data from the PHDC suggested an MTCT of 1.8% by the end of the index period (the PHDC HIV episode identified an additional 16 HIVexposed (HEI) infants with HIV who were not detected by laboratory tests). PWLHIV who started ART prior to the first antenatal visit had 50% reduced risk of MTCT compared to those who started ART during the pregnancy. Women who were not suppressed antenatally had a 5- fold (aOR = 5.3, 95% CI: 2.5 – 12.3) increased MTCT risk compared to those were suppressed antenatally. Women who did not attend ANC were at highest risk of transmission (aOR=1.6,95%CI: 0.7 – 3.6). iv Conclusion: Although women most women present to care already knowing their HIV status, ART initiation and uptake of viral load testing is very low at presentation but improved significantly during pregnancy, evidence of maturing PMCT services. National and Provincial MTCT is likely to be underestimated as it relies solely on PCR results; the uptake of the birth PCR among HIV-exposed infants is still not 100% (where it should be) and the uptake of a repeat tests among infants that tested negative is even lower. PHDC data, which consolidates HIV data from multiple sources, revealed a higher MTCT than HIV-PCR testing alone.

To address the current leadership challenges within the South African health system, it is important to understand what influences the nature and practice of leadership within healthcare organisations. This thesis presents research about the interlinkages between context, leadership practices and staff satisfaction and morale – as indicators of leadership effectiveness - in district hospitals. The study represents one of the few detailed empirical inquiries into these issues in South Africa and adds to the still limited body of relevant empirical evidence in low- and middle-income countries. The research specifically drew on organisational and leadership theory to shape its strategies of data collection and analysis. It was conducted in two case study, district-level, hospitals. Multiple sources of data were collected, including document reviews, non-participant observations, and in-depth qualitative interviews. Data from staff satisfaction surveys carried out separately from this study were also considered. The in-depth interviews involved the three broad cadres of clinical, nursing, and administrative staff working within the hospitals, including those with and without formal managerial roles. Thematic analysis was applied in analysing experience in each case study hospital and also in cross-case analysis. This analysis involved iterative inductive, deductive, and abductive processes. The thesis generates insights about the leadership practices experienced in the case study hospitals that may both engender (positive practices) or undermine (negative practices) staff satisfaction and morale. Positive leadership practices also nurtured the collective leadership that itself enhanced teamworking and influenced the hospital context to spread collective leadership more widely. These leadership practices were, in turn, influenced by contextual elements internal and external to the hospital, some of which themselves had possible consequences for staff satisfaction and morale. Critical features of hospital external context included hospitals' histories and backgrounds, as well as the wider bureaucratic context of rigidity in which they are situated. Key features of hospital internal context influencing collective leadership were, meanwhile, internal power structures and processes, professional identity, and cross-professional relationships. This analysis of the interactions between hospital context, collective leadership and staff satisfaction and morale illuminates the complex dynamics of hospitals. This Leadership Trinity offers insights of relevance to health system reform in South Africa, and more specifically, to implementation of current National Health Insurance proposals.

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The growing burden of HIV and non- communicable disease (NCD) syndemic in Sub Saharan Africa, has necessitated introduction of integrated models of care in order to leverage existing HIV care infrastructure for NCDs. However, there is paucity of literature on long term treatment outcomes for multimorbid patients attending integrated care. We describe long term treatment outcomes among multimorbid patients who attended integrated ART and NCD clubs (IC), a novel model of care piloted in 2014 by the Western Cape Government in South Africa. We followed up multimorbid patients for 12 months, who enrolled for IC at Matthew Goniwe and Town II clinics before September 2016. Median adherence proportions, HIV viral suppression and retention rates were calculated at 12 months before and after IC enrolment. Rates for achieving targets for blood pressure and glycosylated haemoglobin were determined at 12 months prior, at IC enrolment and at 12 months post IC enrolment. We describe demographic and clinical variables among all patients at IC enrolment and used multivariable logistic regression to evaluate for predictors of NCD control 12 months post IC enrolment. As of 31 August 2017, 247 patients in total had been enrolled into IC for at least 12 months. Of these, 221 (89.5%) had hypertension, 4 (1.6%) had diabetes mellitus and 22 (8.9%) had both in addition to HIV. Adherence was maintained before and after IC enrolment with median adherence proportions of 1 (IQR 1-1) and 1 (IQR 1-1) respectively. HIV viral suppression rates were 98.6%, 99.5% and 99.4% at the three time points respectively. Retention in care was high with 6.9% lost to follow up at 12 months post IC enrolment. Optimal blood pressure control was achieved in 43.1%, 58.9% and 49.4% of participants whereas optimal glycaemic control was achieved in 47.4%, 87.5% and 53.3% of diabetic participants at the three time points respectively. Multivariable logistic analyses showed no independent variables significantly associated with NCD control. Multi-morbid people living with HIV achieved high levels of HIV control in integrated HIV and NCD clubs. However, intensified interventions are needed to maintain NCD control in the long term.

Includes bibliographical references. / The purpose of this study was to review past SL projects that have been implemented by GEMP 1 and 2 students, in order to inform the future planning and conduct of the SL programme in the faculty. A document review of all available Power Point presentations for projects implemented from 2006 - 2011 was undertaken employing content analysis. Of approximately 286 projects completed, 183 documents were available for review.

Includes bibliographical references. / [Background] Tuberculosis is a major public health concern for South Africa which has one of the highest recorded incidence rates in the world. Previous research [1998 South African Demographic and Health Survey (SADHS)] reported a crude association between alcohol use and tuberculosis. This study aimed to examine evidence for a relationship, and the size thereof, between alcohol consumption and previous tuberculosis in the 2003 SADHS as a means of informing tuberculosis prevention. [ Methods ] This study was a secondary analysis of cross sectional data collected as part of the 2003 SADHS. Tuberculosis lifetime risk was derived from respondent reports of past tuberculosis episodes based on being informed by a healthcare worker. Alcohol consumption, problem drinking as well as selected explanatory variables were generated from similar questions from the adult questionnaire of the SADHS. The CAGE questionnaire was used to measure symptoms of alcohol problems. Logistic regression was used to model the relationship between past tuberculosis and both alcohol consumption and CAGE. [ Results ] Current and previous alcohol consumption were found to be associated with an increase in odds of tuberculosis in both men and women, with odds ratios ranging iii from 1.1 (95% CI 0.9 - 2.5) to 2.8 (95% CI 1.4 - 5.7) after adjusting for potential confounding effects of socioeconomic factors, smoking, nutritional status and age. Having a CAGE score of either 1 to 2 or 3 to 4 was associated with a doubling [OR 2.2 (95% CI 1.0 - 4.8) and quadrupling [OR 4.4 (95% CI 1.4 - 13.4)] in the odds of tuberculosis respectively. [ Discussion ] and conclusion Behavioural and biological mechanisms of effect of alcohol on tuberculosis may explain the findings. Impairment of the immune system, both acute and long term, has been suggested as the mechanism of increased susceptibility to tuberculosis. On the other hand, high risk living conditions and behaviour associated with problem drinking provide potential for increased exposure and susceptibility to tuberculosis infection. The study was able to control for several potentially confounding socioeconomic predictor variables although not HIV infection. The results complement a body of research that has documented the adverse effects of alcohol consumption on health in general and tuberculosis specifically. The findings thus provide more evidence for public health practitioners to tackle the problem of tuberculosis via specific efforts to control alcohol use and abuse, in addition to other methods of tuberculosis control.