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11	Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland Witt, Anke, Mateska, Ivona, Palladini, Alessandra, Sinha, Anupam, Wölk, Michele, Harauma, Akiko, Bechmann, Nicole, Pamporaki, Christina, Dahl, Andreas, Rothe, Michael, Kopaliani, Irakli, Adolf, Christian, Riester, Anna, Wielockx, Ben, Bornstein, Stefan R., Kroiss, Matthias, Peitzsch, Mirko, Moriguchi, Toru, Fedorova, Maria, Grzybek, Michal, Chavakis, Triantafyllos, Mirtschink, Peter, Alexaki, Vasileia Ismini 14 August 2024 (has links) Corticosteroids regulate vital processes, including stress responses, systemic metabolism, and blood pressure. Here, we show that corticosteroid synthesis is related to the polyunsaturated fatty acid (PUFA) content of mitochondrial phospholipids in adrenocortical cells. Inhibition of the rate-limiting enzyme of PUFA synthesis, fatty acid desaturase 2 (FADS2), leads to perturbations in the mitochondrial lipidome and diminishes steroidogenesis. Consistently, the adrenocortical mitochondria of Fads2−/− mice fed a diet with low PUFA concentration are structurally impaired and corticoid levels are decreased. On the contrary, FADS2 expression is elevated in the adrenal cortex of obese mice, and plasma corticosterone is increased, which can be counteracted by dietary supplementation with the FADS2 inhibitor SC-26192 or icosapent ethyl, an eicosapentaenoic acid ethyl ester. In humans, FADS2 expression is elevated in aldosterone-producing adenomas compared to non-active adenomas or nontumorous adrenocortical tissue and correlates with expression of steroidogenic genes. Our data demonstrate that FADS2-mediated PUFA synthesis determines adrenocortical steroidogenesis in health and disease. info:eu-repo/classification/ddc/500 ddc:500
12	Investigations on the effects of dietary insoluble and soluble non-starch polysaccharides (NSP) on host-parasite interactions in laying hen chicks infected with Heterakis gallinarum or Ascaridia galli / Untersuchungen zum Einfluß löslicher und unlöslicher Nicht-Stärke-Polysaccharide (NSP) im Futter auf Parasit-Wirt-Interaktionen bei wachsenden Junghennen Daş, Gürbüz 16 November 2010 (has links) No description available. 630 Landwirtschaft Veterinärmedizin Agricultural Sciences NSP Nicht-Stärke-Polysaccharide Futter Parasit-Wirt-Interaktionen Junghennen Helminthen Heterakis gallinarum Ascaridia galli Histomonas meleagridis Fettsäure Rohfaser Parasitenfruchtbarkeit non starch polysaccharides NSP host-parasite interactions laying hens Helminth Heterakis gallinarum Ascaridia galli Histomonas meleagridis SCFA Dietary fibre parasite fecundity EPG egg 48.60 48.61 46.52 YF 000: Haustiere Insektenzucht Tierzucht und Tierhaltung YFP 000: Tierernährung Tierfutter {Tierhaltung}

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Fatty acid desaturase 2 determines the lipidomic landscape and steroidogenic function of the adrenal gland