Sensors have become essential elements in human life for safe and comfortable existence in the ever demanding world. Various technologies over decades have contributed in their own way fulfilling innumerable sensing requirements. The discovery of optical sensor technologies has revolutionized the sensing field due to their inherent advantages. Among the large number of fiber optic sensor technologies, FBG based sensors have become widely known and popular within and outside the photonics community and has seen a prominent rise in their utilization. This thesis explores the use of FBG sensors for a wide range of applications scanning across a variety of engineering and medical applications, in the areas of civil engineering, biomechanical engineering, aerospace engineering, geoengineering, etc. It also deals with newer methods of packaging FBG sensors for the measurement of specific engineering parameters like strain, temperature, pressure, displacement and vibration. In the field of civil engineering, FBG sensors are employed for strain sensing on a prism and furthermore tested on a full size brick wallet. During this study, emphasis is made on substituting traditional sensors by specially packaged FBG sensors with the intent of either enhancing the sensing system’s performance or in merging/uniting the inherent advantages of FBG sensors. In the area of biomechanics, a novel sensor methodology using FBG sensors, for measuring surface strains generated on the skin of the calf muscle during various leg exercises is proposed. This methodology is used to address one of the most critical and life threatening issues in long distance air travel, namely the Deep Vein Thrombosis. Further, a FBG sensor based plantar sensing plate, is designed and developed, to measure plantar strain distribution in foot and also to analyze the postural stability. In the field of aerospace engineering, FBG sensors are used for addressing two of the most vital issues; Structural Health Monitoring (SHM) and direct measurement of pressure and temperature on the surface of an aircraft under hypersonic wind flow. Carbon Fiber Composite coupon level testing is carried out to obtain a generic strain calibration factor for the FBG sensor. Further, FBG sensors are exploited for the direct measurement of absolute temperature and pressure on the leeward surface of blunt cone at hypersonic wind speeds. In the domain of geoengineering, the feasibility studies have been undertaken to use a FBG as a seismic sensor and as a bore-well characterizing sensor. A novel FBG seismic sensor package is developed using a single FBG sensor to pick up the seismic waves propagating through the ground generated from earthquakes and ground tremors. Further, FBG sensors are used for measurement of temperature profiles in a bore-well to delineate and characterize the behavior of fractures during seasonal climatic changes. To summarize, the present thesis demonstrates a comprehensive experimental study which bring out the utility of FBG sensors in a variety of challenging applications.