Gas Sensing Has Become a Very Important and Attractive Technique Because of Its Various Applications, Such as in the Increasingly Concerning Case of Environmental Issues, Automobile Emission Detection, Natural Gas Leakage Detection, Etc. It Also Has Significant Applications in Industries, Such as Safety and Health Monitoring in Underground Mines. Among Those Sensing Areas, Fiber-optic Sensors Have Drawn Considerable Attention Because of Its Small Size, Light Weight, High Sensitivity, and Remote Sensing Capability. However, Current Fiber-optic Gas Sensing Techniques Have Several Limitations on Their Potential for Multiplexed or Distributed Sensing Due to Difficulties Such as High Complexity or Large Loss. To Accomplish the Goal for Multiplexed Gas Sensing, an Off-centered Core Fiber Design Is Investigated. The Eccentric Core Can Reduce Attenuation, Keep Mechanical Strength, and Lower Fabrication Cost. To Verify the Feasibility of the Design, Fiber Field Distribution Is First Studied in Simulation, Which Will Be Discussed in Detail in Chapter 2. Then Two Fiber Samples with a Length of 10 Cm and 40 Cm Are Prepared and Placed in a Custom Methane Sensing System for Gas Absorption Testing, Which Is Detailed in Chapter 3. From Etching Analysis, Localized Surface Defects Are Found as the Main Reason for Power Loss. Performance Such as Detection Resolution and Sensitivity Are Investigated. In Chapter 4, Theoretical Evaluations Have Been Conducted for Multiplexed Sensors Performances Using the Off-centered Core Fiber to Study the Impact Fiber Parameters on Sensing System Design. The Conclusion and Summary Are Presented in Chapter 5. / Master of Science / Gas Sensing Has Become a Very Important and Attractive Technique Because of Its Various Applications, Such as in the Increasingly Concerning Case of Environmental Issues, Automobile Emission Detection, Natural Gas Leakage Detection, Etc. It Also Has Significant Applications in Industries, Such as Safety and Health Monitoring in Underground Mines. Among Those Sensing Areas, Fiber-optic Sensors Have Drawn Considerable Attention Because of Its Small Size, Light Weight, High Sensitivity, and Remote Sensing Capability. However, Current Fiber-optic Gas Sensing Techniques Have Several Limitations on Their Potential for Long Distance Distributed Sensing Due to Difficulties Such as High Fabrication Complexity. In This Work, a Fiber-optic Gas Sensor with Special Structure Was Designed. The Sensor Can Reduce Attenuation, Keep Mechanical Strength, and Lower Fabrication Cost. To Verify the Feasibility of the Design, Theory Analysis and Simulation Were Conducted, Which Will Be Discussed in Detail in Chapter 2. Then Two Samples with a Length of 10 Cm and 40 Cm Were Prepared and Placed in a Custom Methane Sensing System for Testing. And Their Performance Such as Sensitivity Is Investigated. In Chapter 4, Theoretical Evaluations Have Been Conducted for Multiplexed Sensors Performances Evaluation to Study the Impact Fiber Parameters on Sensing System Design. The Conclusion and Summary Are Presented in Chapter 5.