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1	Computational studies of the human cardiac sodium channel Beard, Torien M. 08 December 2023 (has links) (PDF) Computational methods such as Molecular Dynamics (MD) simulations and Molecular Mechanics generalized Born surface area solvation (MM-GBSA) binding affinity calculations have been utilized to determine the binding modes and final binding affinities of small molecules that are known to interact with the heart sodium channel NaV1.5. Lidocaine, ranolazine, and flecainide are FDA approved arrhythmia drugs that are prescribed to patients in the event of heart disease. Here, we demonstrate the likely binding preferences and modes of action of all molecules with NaV1.5, the stability of the systems, and overall final binding affinities of the small molecules with the protein. To gain insights into the mechanisms of heart disease treatments, the MM-GBSA method was utilized to estimate the binding free energies of each molecule and pose to NaV1.5. The evaluation of the binding of small molecules to NaV1.5 contributes to enhancing our understanding of the underlying processes involved in heart disease treatments. The MM-GBSA approach provides a valuable tool for predicting and analyzing binding affinities, which can aid in the design and optimization of potential therapeutic compounds targeting NaV1.5. Sodium channel Lidocaine Ranolazine Flecainide
2	Real-Time Monitoring of Healthcare Interventions in Routine Care : Effectiveness and Safety of Newly Introduced Medicines Cars, Thomas January 2016 (has links) Before market authorization of new medicines, their efficacy and safety are evaluated using randomized controlled trials. While there is no doubt about the scientific value of randomized trials, they are usually conducted in selected populations with questionable generalizability to routine care. In the digital data revolution era, with healthcare data growing at an unprecedented rate, drug monitoring in routine care is still highly under-utilized. Although many countries have access to data on prescription drugs at the individual level in ambulatory care, such data are often missing for hospitals. This is a growing problem considering the clear trend towards more new and expensive drugs administered in the hospital setting. The aim of this thesis was therefore to develop methods for extracting data on drug use from a hospital-based electronic health record system and further to build and evaluate models for real-time monitoring of effectiveness and safety of new drugs in routine care using data from electronic health records and regional and national health care registers. Using the developed techniques, we were able to demonstrate drug use and health service utilization for inflammatory bowel disease and to evaluate the comparative effectiveness and safety of antiarrhythmic drugs. With a rapidly evolving drug development, it is important to optimize the evaluation of effectiveness, safety and health economic value of new medicines in routine care. We believe that the models described in this thesis could contribute to fulfil this need. Electronic Health Records Comparative Effectiveness Research Comparative Safety Research Sequential drug monitoring propensity score real-world data infliximab TNF-inhibitors dronedarone amiodarone flecainide
3	Einfluss der Antiarrhythmika Flecainid und Amiodaron auf die kontraktile Funktion und die Kraft-Frequenz-Beziehung des Herzens / Influence of the antiarrhythmic drugs Flecainide and Amiodarone on the contractile function and the force-frequency-relationship of the heart Pagel, Christian 09 August 2010 (has links) No description available. 610 Medizin, Gesundheit Medicine Flecainid Amiodaron Herzinsuffizienz diastolische Funktion Kraft-Frequenz-Beziehung Flecainide Amiodarone heart failure diastolic function force-frequency-relationship 44.85 MED 411: Kardiologie
4	NaV1.5 Modulation: From Ionic Channels to Cardiac Conduction and Substrate Heterogeneity Raad, Nour 16 January 2014 (has links) No description available. 571.4 Antiarrhythmic drugs Optical Mapping Action potential duration Spatial dispersion of repolarization Cardiac depolarization Conduction velocity Anisotropy Duchenne muscular dystrophy mdx - mouse model Dystrophin ΔKPQ mouse model Long QT Syndrome 3 Cardiac Sodium Channel (NaV1.5) Flecainide Maximum upstroke velocity Least Squares Ellipsis Fitting Method Area Fitting Method Plane Fitting Method Conduction abnormalities Voltage sensitive dyes Cardiac arrhythmia Functional heterogeneity Spatial-temporal heterogeneity Proarrhythmia Activation maps Symmetry breaking Intrinsic cardiac heterogeneity Biologie (PPN619462639)

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