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This master’s thesis is focused on the description and processing of the cell method, which is generally recommended for prediction of fluids temperature profiles in heat exchanger. In the thesis the basic equations for calculating heat transfer are presented and is also described the current situation in the field of computational prediction of fluids temperature profiles in heat exchangers. The cell method is solved by using the software Maple and is applied to the specific case of industrial heat exchangers. The results obtained by the cell method are compared with the results obtained by educational version of software HTRI Xchanger Suite. By this comparison explicitness of the cell method is assessed.