Ce travail, effectué dans le cadre d'une convention de recherche avec la Société ISOCHEM, a pour objectif la mise au point d'un nouveau procédé de synthèse de la pyrazolidine par la voie Raschig directe et par voie indirecte, en transitant par la 1 et 2-pyrazoline, suivie d'une hydrogénation catalytique. Cette hydrazine suscite un grand intérêt en raison de ses nombreuses applications dans l'industrie pharmaceutique et des cosmétiques. Cette thèse a été financée par le Centre National de Recherche Scientifique dans le cadre d'une bourse doctorale ingénieure/PED. La première partie est consacrée à l'étude du procédé Raschig direct qui résulte de l'action de l'hypochlorite de sodium sur un excès d'amine. La définition du process a nécessité la détermination des cinétiques et des mécanismes réactionnels afin de déterminer les rendements, les temps de séjour et de simuler numériquement l'ensemble des opérations de synthèse. Les conditions d'extraction ont été établies en exploitant les particularismes des équilibres entre phases impliqués afin d'élaborer le flow-sheet correspondant. La seconde partie est relative à la voie indirecte. Elle est basée sur l'élaboration de la 1- pyrazoline par une double déshydrohalogénation du N,N-dichloro-1,3 diaminopropane. La pyrazolidine est ensuite obtenue par hydrogénation catalytique du groupe azo. Un modèle global d'élaboration de la pyrazolidine a été établi qui nous a permis de déterminer les conditions optimales et de définir les segments synthèses et extractions ainsi que les différentes opérations unitaires du procédé ainsi que les bilans matière et énergie / This work, conducted as part of a research agreement with the Company ISOCHEM, aims to develop a new synthesis of pyrazolidine by the raschig method and by indirect way via 1 and 2-pyrazoline followed by catalytic hydrogenation. This hydrazine is very important, because of its many applications in the pharmaceutical and cosmetic industries. This thesis was funded by the National Center for Scientific Research as part of a doctoral fellowship engineer / PED. The first part is devoted to the study of the direct Raschig process resulting from the action of sodium hypochlorite in an excess of amine. The definition of the process involved the determination of the kinetic and reaction mechanisms to determine yields, residence time and to simulate numerically the overall operations of synthesis. The extraction conditions were established by exploiting the peculiarities of the phase equilibria in order to developed the flow-sheet. The second part relates to the indirect way. It is based on the synthesis of the 1 pyrazoline by double dehydrohalogenation of N,N-dichloro-1,3-diaminopropane. The pyrazolidine is then obtained by catalytic hydrogenation of the azo group. A global model for developing the pyrazolidine was established which allowed us to determine the optimum conditions and to identify segments syntheses and extractions as well as various unit operations of the process and the mass and energy balances

Background: Type 2 diabetes mellitus (T2DM) is a complex health condition that impacts multiple organ systems and contributes to both acute and chronic health problems. In the United States (U.S.), T2DM is a growing health concern with increasing prevalence among both adult and pediatric populations (American Diabetes Association [ADA], 2015; Dea, 2011). Developing a comprehensive plan of care that incorporates a multifaceted treatment and prevention plan is necessary to address this growing health concern and reduce overall morbidity and mortality. Problem: The Edmund Primary Care (EPC) practice data for routine annual diabetic foot exams, annual eye exams, annual urine microalbumin, smoking cessation education and recommendations for pneumococcal polysaccharide do not meet the ADA (American Diabetes Association, 2015) recommendations for patients with T2DM.Design: Quality improvement (QI) project applying the Plan-Do-Study-Act (PDSA) cycle to develop a process change to improve diabetic preventative care measures for hemoglobin A1C, urine microalbumin, diabetic foot exams, and optometry referrals. Setting: A small, nurse practitioner owned, family practice clinic targeting patients 18 years and older with a diagnosis of T2DM.Intervention: A fishbone diagram to conduct a root cause analysis led to identification of key factors contributing to the problem. A comprehensive process change integrating a Diabetic Assessment Flow Sheet (DAFS) and diabetic foot exam sheet was developed to address the problem. Expected Outcome: Increase in rates of completion to at least 90% over eight weeks. Results: Analyzed with run charts demonstrating an increase in rates of completion to 100% for A1C, urine microalbumin, diabetic foot exams, and optometry referrals. A positive percent of change for each measure is as follows: A1C 7%; urine microalbumin 43%; diabetic foot exams 150%; and referrals to optometrist 43%. Significance: This QI project emphasizes the importance of implementing a system to evaluate the quality of care being delivered. It also highlights the usefulness of the PDSA cycle as a method to implementing quality improvement measures in health care. Lastly, this QI project demonstrated the effectiveness of flow sheets in improving the quality of care delivered to patients with T2DM.

Scope of this thesis is the design and evaluation of a laundry processing facility. Main goal was to prepare, design and evaluate part of the technological layout for a modern, high-volume laundry processing facility. The focus was on the main apparatuses, main process flow, as well as the supporting process flow, related equipment and key components of field instrumentation with standard description. 3D facility model was prepared on the basis of proposed technological layout, using the SolidWorks software package. This model shows placement of all key equipment and components as well as physical disposition of connection tubing within the building. Final part of work reviews proposed options of process parameters measurement. Such measurements which are important for the evaluation of energy consumption of considered laundry processing. We discuss both pros and cons of evaluated and selected suitable measurement devices, tools and procedures. Constructed 3D model of piping lines shows placing and dimensions of selected measurement devices.