The objective of this paper is to present an efficient miniaturized antenna design and simulation of a highly isolated multi-port micro-strip antenna for multiple-input multiple-output communication (MIMO) systems. Three geometric configurations were proposed and compared to achieve an isolation of as low as –30 dB without affecting the antenna performance greatly. The antenna was designed to operate at a resonance frequency of 2.45 GHz (fc ). Ferrite material beneath each meander structure was used for miniaturization purposes as well as an FR4 substrate with a compact overall area of .75 lambda0 ×.5 lambda0 for a system board, where lambda0 is the free space wavelength. A ground plane with small etched slits was used for isolation purposes. A maximum gain of 4.6 dBi in the azimuthal plane was achieved. Index Terms: MIMO, meander antenna, four-port antenna, defected ground structure / Thesis (M.S.)--Wichita State University, College of Engineering, Dept. of Electrical Engineering and Computer Science