Šio darbo metu tirta skirtingų rTMS parametrų įtaka galvos smegenų bioelektriniam aktyvumui. Atlikus EEG duomenų spektrinę analizę, pademonstruota, jog aukšto dažnio rTMS virš KPFDLŽ, skirtingai nuo žemo dažnio rTMS virš DPFDLŽ, stimuliuojant aštuoniukės formos rite, statistiškai patikimai padidina alfa bangų dažnių diapazono absoliučią galią dešiniajame pusrutulyje. Paminėtina ir tai, kad po gydymo kurso rTMS aštuoniukės formos rite Kleino protokolu, skirtingai nei klasikiniu protokolu, frontalinėje srityje alfa bangų dažnio diapazone statistiškai reikšmingai sumažėja (F7-F8)/(F7+F8) asimetrijos koeficientas. Svarbu pažymėti, jog po rTMS stimuliacijos apvalia rite, palyginus su stimuliacija aštuoniukės formos rite, registruojami labiau išplitę, sudėtingesni smegenų bioelektrinio aktyvumo pokyčiai. / Recently rTMS emerged as a new clinical tool for the treatment of major depressive disorder. rTMS is noninvasive and easily tolerated method that is able to alter bioelectrical brain activity. This phenomenon is achieved by using alternating magnetic fields to induce electric currents in cortical tissue. Nowadays it is widelly accepted that lateralized alterations in brain activity might play a role in depressive symptoms. It has been found that major depressive disorder patients exhibit greater right frontal activity in contrast to left frontal hypoactivation (it should be noted, that cortical activity is inversely related with alpha power). Therefore rTMS is a potential method that can help to re-eastablish normal brain activity. In this study we examined effects of different rTMS parameters (protocols and stimulation coils) on bioelectrical brain activity modulation in patients with the treatment resistant major depressive disorder. It was shown that 10 Hz stimulation with the figure-eight coil over the left prefrontal area increases alpha power in the right hemisphere. In addition, it was demonstrated that 1 Hz stimulation over the left prefrontal cortex changes frontal alpha asymmetry. It should be underlined, that there appears to be no significant difference in clinical efficacy between the two protocols. It was also demonstrated that changes in frontal alpha asymmetry tend to correlate with the outcome of the treatment. Furthermore, it was shown that stimulation with... [to full text]