Societal concerns on combustion-based fuel consumption are ever-increasing. With respect to internal combustion engines, this translates to a need to increase brake fuel conversion efficiency (BFCE). Diesel engines are a relatively efficient internal combustion engine to consider for numerous applications, but associated actions to mitigate certain exhaust emissions have generally deteriorated engine efficiency. Conventionally, diesel engine emission control has centered on in-cylinder techniques. Although these continue to hold promise, the industry trend is presently favoring the use of after-treatment devices which create new opportunities to improve the diesel engine's brake fuel conversion efficiency. This study focuses on injection timing effects on the combustion processes, engine efficiency, and the engine system's responses. The engine in the study is a medium duty diesel engine (capable of meeting US EPA Tier III off road emission standards) equipped with common rail direct fuel injection, variable geometry turbo charging, and interfaced with a custom built engine controller. The study found that injection timing greatly affected BFCE by changing the combustion phasing. BFCE would increase up to a maximum then begin to decrease as phasing became less favorable. Combustion phasing would change from being mostly mixing controlled combustion to premixed combustion as injection timing would advance allowing more time for fuel to mix during the ignition delay. Combustion phasing, in turn, would influence many other engine parameters. As injection timing is advanced, in-cylinder temperatures and pressures amplify, and intake and exhaust manifold pressures deteriorate. Rate of heat release and rate of heat transfer increase when injection timing is advanced. Turbocharger speed falls with the advancing injection timing. Torque, however, rose to a maximum then fell off again even though engine speed and fueling rate were held constant between different injection timings. Interestingly, the coefficient of heat transfer changes from a two peak curve to a smooth one peak curve as the injection timing is advanced further. The major conclusion of the study is that injection advance both positively and negatively influences the diesel engine's response which contributes to the brake fuel conversion efficiency.