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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Onicomicoses: Perfil de fungos não dermatófitos em pacientes ambulatoriais da Fundação Alfredo da Matta - Manaus/Amazonas

Aquino, Sandra Regina Sales de Menezes, (92)99500-2323 29 September 2004 (has links)
Submitted by Thais Lopes (th.lopes1598@gmail.com) on 2018-11-05T14:26:39Z No. of bitstreams: 1 Dissertação Sandra Aquino.pdf: 1804430 bytes, checksum: 3631232575fab64b76167abb06c64434 (MD5) / Approved for entry into archive by Marcos Roberto Gomes (mrobertosg@gmail.com) on 2018-11-05T17:57:03Z (GMT) No. of bitstreams: 1 Dissertação Sandra Aquino.pdf: 1804430 bytes, checksum: 3631232575fab64b76167abb06c64434 (MD5) / Approved for entry into archive by Divisão de Documentação/BC Biblioteca Central (ddbc@ufam.edu.br) on 2018-11-05T19:00:39Z (GMT) No. of bitstreams: 1 Dissertação Sandra Aquino.pdf: 1804430 bytes, checksum: 3631232575fab64b76167abb06c64434 (MD5) / Made available in DSpace on 2018-11-05T19:00:39Z (GMT). No. of bitstreams: 1 Dissertação Sandra Aquino.pdf: 1804430 bytes, checksum: 3631232575fab64b76167abb06c64434 (MD5) Previous issue date: 2004-09-29 / The role of non-dermatophyte fungi, as it is controversial in the pathogenesis of onychomycosis, requires careful laboratory examination. Both filamentous fungi and yeasts can mimic the dermatophytoses. In this context, this research aimed to observe the mycological profile of nondermatophytic fungi on the etiology of onychomycosis in patients from the Amazon Region and to relate the etiological agents to the types of lesions and the probable predisposing factors. We examined 25 volunteers of both genders presenting 61 nails with lesions suggestive of onychomycosis. The collected clinical material was submitted to clarification with 40% Potassium Hydroxide solution. For the isolation of fungi, part of the clinical material was seeded on Sabouraud agar with chloramphenicol (100 mg / L) and Sabouraud agar plus chloramphenicol (100 mg / L) and 1% olive oil, both cultures were incubated at 25 ° C e 37ºC, respectively. The growth of the microorganisms was observed, every 24 hours, for 30 days. From the 25 patients examined, in 20 the parasitism by filamentous fungi and / or yeasts was confirmed. From the 61 ungual samples, in 72% (44) onychomycoses were diagnosed. According to the results obtained, the onychomycosis patients, 65% female and 35% male, had an age range of 31-50 years old (50%). Among these, there were patients with only hands fingernails (50%), only 25% of the toenails. In the others, 25% had both toenails and hands nails. The professional activity with the largest number of patients was housekeeper (25%), in which the nails of the hands (19%) were more affected. Concerning nails, the halluxes (40.91%) were the most affected. Distal-lateral subungual onychomycosis (OSDL) was observed in 66% of cases, mainly affecting the toenails (43%). The contact with moisture was the most important risk factor reported by patients who had hand nail injuries (45%). The prevalence of non-dermatophytic fungi (90.9%) was observed, among which yeasts were the most frequent (52.7%). Mixed infections (18%) by non-dermatophytic fungi affected 18% of the nails. Among the 53 isolates, 98% of the Deuteromycota phylum and 2% of the Ascomycota phylum were observed. Candida albicans was the predominant species (30%). Among non-dermatophyte filamentous fungi, Aspergillus candidus (4%) and A. niger (4%) were the most frequent. In 8% of cases, Trichophyton tonsurans were diagnosed. Candida albicans was predominant in single agent onychomycosis (28%) affecting mainly female toenails (9%) and male hand nails (9%) occurred more frequently in patients from 31 to 40 years old (12 %), With subungual distal-lateral onychomycosis (16%) being the most common clinical form. It is suggested, with the results of this research, on the etiology of onychomycosis, that non-dermatophyte fungi - both yeasts and filaments - cannot be excluded only by clinical examination, alerting to the importance of laboratory examination and, thus, increasing the chance of success. / O papel dos fungos não dermatófitos por ser controverso na patogenia das onicomicoses há a necessidade de proceder exame laboratorial criterioso. Tanto os fungos filamentosos quanto as leveduras podem mimetizar as dermatofitoses. Nesse contexto, esta pesquisa teve como objetivo observar o perfil micológico dos fungos não dermatófitos na etiologia das onicomicoses em pacientes oriundos da Região Amazônica e relacionar os agentes etiológicos com os tipos de lesões e os prováveis fatores predisponentes. Foram examinados 25 voluntários de ambos os sexos apresentavam 61 unhas com lesões sugestivas de onicomicoses. O material clínico coletado foi submetido à clarificação com solução de Hidróxido de Potássio 40%. Para o isolamento dos fungos, parte do material clínico foi semeado em ágar Sabouraud com cloranfenicol (100 mg/ L) e ágar Sabouraud acrescido de cloranfenicol (100 mg/L) e óleo de oliva 1%, ambos os cultivos foram incubados a 25ºC e 37ºC, respectivamente. O crescimento dos microrganismos foi observado, a cada 24 horas, por 30 dias. Dos 25 pacientes examinados, em 20 foi confirmado o parasitismo por fungos filamentosos e/ou leveduras. Das 61 amostras ungueais, em 72% (44) foram diagnosticadas onicomicoses. De acordo com os resultados obtidos, os portadores de onicomicoses, 65% do sexo feminino e 35% do masculino, a faixa etária oscilava entre 31-50 anos (50%). Entre esses, houveram pacientes que apresentavam acometimento apenas das unhas das mãos (50%), 25% apenas das unhas dos pés. Nos demais, 25% constatou-se acometimento tanto das unhas dos pés quanto das mãos. A atividade profissional com maior número de pacientes foi de domésticas (25%), nas quais as unhas das mãos (19%) foram mais acometidas. Com relação as unhas acometidas, os háluxes (40,91%) foram os mais afetados. A onicomicose subungueal distal-lateral (OSDL) foi observada em 66% dos casos, acometendo principalmente as unhas dos pés (43%). O contato com umidade foi o mais importante fator de risco relatado pelos pacientes que apresentavam lesões das unhas das mãos (45%). Constatou-se a predominância de fungos não dermatófitos (90,9%), dentre os quais as leveduras foram as mais frequentes (52,7%). Infecções mistas (18%) por fungos não dermatófitos acometeram 18% das unhas. Dentre os 53 isolados observou-se 98% do Filo Deuteromycota e 2% do Filo Ascomycota. Candida albicans foi a espécie predominante (30%). Dentre os fungos filamentosos não dermatófitos, Aspergillus candidus (4%) e A. niger (4%) foram os mais frequentes. Em 8% dos casos diagnosticarem-se Trichophyton tonsurans. Candida albicans foi predominante em onicomicose por agente único (28%) acometendo principalmente unhas dos pés no sexo feminino (9%) e unhas das mãos no masculino (9%), ocorreu mais freqüentemente em pacientes com 31 a 40 anos de idade (12%), sendo a onicomicose subungueal distal-lateral (16%) a forma clínica mais comum. Os resultados desta pesquisa se comprovaram que os fungos não dermatófitos são agentes frequentes de onicomicoses o que alerta para serem incluídos como suspeitos no diagnóstico etiológico das mesmas.

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