Thesis (Ph. D.)--University of Missouri-Columbia, 1998. / Typescript. Vita. Includes bibliographical references (leaves 216-229). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1998. / Typescript. Vita. Includes bibliographical references (leaves 216-229). Also available on the Internet.

Thesis (M.S.)--OGI School of Science & Engineering at OHSU, Oct. 2005. / Includes bibliographical references (leave 22).

Thesis (M.Eng.)--Memorial University of Newfoundland, 2003. / Bibliography: leaves 71-74. Also available online.

Thesis (M.Soc.Sc.)--University of Hong Kong, 1991. / Also available in print.

Thesis (Ph. D.)--University of Rhode Island, 2006. / Includes bibliographical references (leaves 99-100).

Local descriptors are increasingly used for the task of object recognition because of their perceived robustness with respect to occlusions and to global geometrical deformations. We propose a performance criterion for a local descriptor based on the tradeoff between selectivity and invariance. In this paper, we evaluate several local descriptors with respect to selectivity and invariance. The descriptors that we evaluated are Gaussian derivatives up to the third order, gray image patches, and Laplacian-based descriptors with either three scales or one scale filters. We compare selectivity and invariance to several affine changes such as rotation, scale, brightness, and viewpoint. Comparisons have been made keeping the dimensionality of the descriptors roughly constant. The overall results indicate a good performance by the descriptor based on a set of oriented Gaussian filters. It is interesting that oriented receptive fields similar to the Gaussian derivatives as well as receptive fields similar to the Laplacian are found in primate visual cortex.

Tuning to an optimal stimulus is a widespread property of neurons in cortex. We propose that such tuning is a consequence of normalization or gain control circuits. We also present a biologically plausible neural circuitry of tuning.

This thesis investigates the application of Kriging meta-modelling techniques in the field of building design and optimisation. In conducting this research, there were two key motivational factors. The first is the need for building designers to have tools that allow low energy buildings to be designed in a fast and efficient manner. The second motivating factor is the need for optimisation tools that account, or help account, for the wide variety of uses that a building might have; so-called Robust Optimisation (RO). This thesis therefore includes an analysis of Kriging meta-modelling and first applies this to simple building problems. I then use this simple building model to determine the effect of the updated UK Test Reference Years (TRYs) on energy consumption. Second, I examine Kriging-based optimisation techniques for a single objective. I then revisit the single-building meta-model to examine the effect of uncertainty on a neighbourhood of buildings and compare the results to the output of a brute-force analysis of a full building simulator. The results show that the Kriging emulation is an effective tool for creating a meta-model of a building. The subsequent use in the analysis of the effect of TRYs on building shows that UK buildings are likely to use less heating in the future but are likely to overheat more. In the final two chapters I use the techniques developed to create a robust building optimisation algorithm as well as using Kriging to improve the optimisation efficiency of the well-known NSGA-II algorithm. I show that the Kriging-based robust optimiser effectively finds more robust solutions than traditional global optimisation. I also show that Kriging techniques can be used to augment NSGA-II so that it finds more diverse solutions to some types of multi-objective optimisation problems. The results show that Kriging has significant potential in this field and I reveal many potential areas of future research. This thesis shows how a Kriging-enhanced NSGA-II multi-objective optimisation algorithm can be used to improve the performance of NSGA-II. This new algorithm has been shown to speed up the convergence of some multi-objective optimisation algorithms significantly. Although further work is required to verify the results for a wider variety of building applications, the initial results are promising.

Modelling interactions between genes and their regulators is fundamental to understanding how, for example a disease progresses, or the impact of inserting a synthetic circuit into a cell. We use an existing method to infer regulatory networks under multiple conditions: the Joint Graphical Lasso (JGL), a shrinkage based Gaussian graphical model. We apply this method to two data sets: one, a publicly available set of microarray experiments perturbing the gram-positive bacteria Bacillus subtilis under multiple experimental conditions; the second, a set of RNA-seq samples of Mouse (Mus musculus) embryonic fibroblasts (MEFs) infected with different strains of the parasite Toxoplasma gondii. In both cases we infer a subset of the regulatory networks using relatively small sample sizes. For the Bacillus subtilis analysis we focused on the use of these regulatory networks in synthetic biology and found examples of transcriptional units active only under a subset of conditions, this information can be useful when designing circuits to have condition dependent behaviour. We developed methods for large network decomposition that made use of the condition information and showed a greater specificity of identifying single transcriptional units from the larger network using our method. Through annotating these results with known information we were able to identify novel connections and found supporting evidence for a selection of these from publicly available experimental results. Biological data collection is typically expensive and due to the relatively small sample sizes of our MEF data set we developed a novel empirical Bayes method for reducing the false discovery rate when estimating block diagonal covariance matrices. Using these methods we were able to infer regulatory networks for the host infected with either the ME49 or RH strain of the parasite. This enabled the identification of known and novel regulatory mechanisms. The Toxoplasma gondii parasite has shown to subvert host function using similar mechanisms as cancers and through our analysis we were able to identify genes, networks and ontologies associated with cancer, including connections that have not previously been associated with T. gondii infection. Finally a Shiny application was developed as an online resource giving access to the Bacillus subtilis inferred networks with interactive methods for exploring the networks including expansion of sub networks and large network decomposition.