Here is provided the first description of Pleistocene lizards recovered from five caves (Baikong, Juyuan, Queque, Sanhe, and Zhiren) in Chongzuo, Zuo River area of Guangxi Zhuang Autonomous Region, southern China. Lizard remains reported here come from faunas that include Gigantopithecus blacki or Homo sapiens dating from the Early to Late Pleistocene with age-range estimates from 2.0Ma to 111ka. The recovery of agamids (Agamidae), skinks (Scincidae), a large species of Gekko, and smaller forms of gekkonids (Gekkonidae) is of interest in that the diversity of lizards for the caves is high given the extremely small sample size from the deposits. The description of cf. Draco reported here is the first indication of the possible occurrence of this genus in the Pleistocene record. Southern China and the adjacent territories in Vietnam and Laos have a diverse lizard fauna today. Cave deposits with established chronologies in the local karst regions such as recovered in Chongzuo, can help record the diversity within the local lizard community through time. Although the fossil lizards reported here appear to represent mammalian prey remains (highly fragmented), caves that contain owl roost pellet deposits might represent a more diverse squamate community with the additional advantage of having specimens that are not as fragmented. Because a Pleistocene-age lizard record does occur in the caves reported here, in all likelihood equivalent deposits should occur in the numerous caves throughout southern China and Southeast Asia.