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A new spatially telescoping approach was proposed to improve measurement flexibility and account for hydrologic scale in field studies of groundwater-surface water (GW-SW) interaction. We applied this spatially telescoping approach in a study GW-SW interactions along Lucile Creek, Alaska. Catchment-scale data were used to screen areas of potentially significant GW-SW exchange, indicating groundwater contribution from a deeper regional aquifer along the middle to lower reaches of the stream. This initial assessment was tested using reach-scale estimates of groundwater contribution during base flow conditions. The reach-scale measurements indicated a large increase in discharge along the middle reaches of the stream accompanied by a shift in chemical composition towards a regional groundwater end member. Point measurements of vertical water fluxes were used to evaluate spatial and temporal variability of GW-SW exchange within representative reaches. The spatially telescoping approach identified locations of GW-SW exchange and improved interpretation of reach-scale and point-scale measurements.