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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Glaucoma congenito primario : uma entidade genetica heterogenea

Maciel-Guerra, Andrea Trevas, 1960- 28 August 1986 (has links)
Orientador: Bernardo Beiguelman / Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia / Made available in DSpace on 2018-07-16T13:36:59Z (GMT). No. of bitstreams: 1 Maciel-Guerra_AndreaTrevas_M.pdf: 1446924 bytes, checksum: 5cf002e9c47d68492f0773d332d2786e (MD5) Previous issue date: 1986 / Resumo: A visão clássica sobre o mecanismo de herança do glaucoma congênito primário é a que essa anomalia é sempre transmitida de modo autossômico recessivo monogênico. A análise dos dados familiais de 1408 portadores dessa anomalia mostra que o glaucoma congênito primário é, na verdade, uma entidade genética heterogênea, visto que foi possível detectar pelo menos duas formas autossômicas monogênicas dessa doença, sendo uma dominante e outra recessiva. Há, ainda, um grande contingente de anômalos cuja etiologia (genética) não fui passível determinar. Assim sendo é fundamental, tanto para o geneticista quanto para o o oftalmologista, que se procure distinguir as diferentes entidades genético-clínicas ao nível anatômico e/ou bioquímico / Mestrado

Factors associated with late presentation of glaucoma: a study in a black South African population.

Kraukamp, Philip 28 March 2014 (has links)
OBJECTIVES: To determine the association between various ocular and non-ocular factors and late presentation of glaucoma. DESIGN & METHOD: This study represents a comparative study between patients who at their first clinic presentation were assessed as having advanced chronic glaucoma and glaucoma patients who presented early in the course of their disease. The study adhered to the tenets of the declaration of Helsinki. 133 Glaucoma patients who attended the St John Eye Hospital in Soweto from December 2008 to October 2009 consented to participate in the study. They completed a questionnaire, underwent a complete ophthalmological examination and their hospital records were reviewed. 68 of the patients were assessed to be 'late presenters' with typical glaucomatous field loss and a mean deviation (MD) of greater than -14 dB in the better seeing eye, as well as typical glaucomatous cupping of 0.8 or more. 65 of the patients were assessed to be 'early presenters' with typical glaucomatous field loss and a MD between 0 dB and -11 dB in the worse eye as well as a cup to disc ratio of 0.5 or more or an interocular difference of 0.2 or greater between the discs. RESULTS: Presenting IOP in 'late presenters' (OD 33.56mmHg +/- 9.61: OS 33.46mmHg +/-10.37) was significantly higher (P<0001) than those of 'early presenters' (OD 18.37mmHg +/-5.95 : OS 19.24mmHg +/- 7.21). Other factors associated with late presentation include poor English language ability (52.9% vs. 16.9%)(P<0001), previous/current rural inhabitants (44.1% vs. 27.7%)(P=0.048), informal housing (17.6% vs. 6.1%)(P=0.041), smoking (16.1% vs.4.6%)(P=0.029) and smaller optic discs [(OD 1.98mm+/-0.27 : OS 1.97mm+/-0.27) vs.(OD 2.11mm+/-0.35 : OS 2.10mm+/-0.37)](P<0.05). A history of previous eye trauma was more common in 'early presenters' (18.4% vs 5.8%)(P=0.025) as was a medical history of diabetes mellitus (33.8% vs 16.1%)(P=0.018). The following factors were found to be statistically insignificant: age, sex, hypertension, primary vascular dysregulation, patient education, a positive family history of glaucoma and the presence of pseudocapsular exfoliation. CONCLUSION: In this patient cohort we found that the IOP at presentation was significantly higher in patients presenting with advanced glaucoma than in those presenting earlier in the disease process. Our data has also identified other factors which may be associated with late presentation.

An epidemiological study of risk factors associated with progression from ocular hypertension to primary open angle glaucoma

Landers, John, January 2001 (has links)
Thesis (M.P.H.)--University of Sydney, 2001. / Includes tables. Title from title screen (viewed Apr. 23, 2008). Submitted in fulfilment of the requirements for the degree of Master of Public Health to the Dept. of Public Health and Community Medicine, Faculty of Medicine. Includes bibliography. Also available in print form.

Risk factors for primary open - angle glaucoma: an epidemiological study

Bulbulia, Aboobaker 22 August 2012 (has links)
M.Phil. / The record cards of all patients (21 554) examined by the eye clinic on the Phelophepa Mobile Health Care train during January and September, 1995 were analysed. The prevalence of. POAG in the sample was 0-.8% (177 of 21 554 persons). Differences in POAG prevalence were observed with respect to sex, age and geographical region. There was a significant difference (p<0.001) in the number of males (1.1%, 92 of 8113), compared to females (0.6%, 85 of 13 441) diagnosed with POAG. In persons over 40 years of age the prevalence rate was 1.2 % (166 of 14 254 persons) and in persons over 60 years the rate was 1.7% (110 of 6375 persons). The highest prevalence rate was found in the Western Cape (1.84%) and the lowest in the Eastern Cape (0.33%). POAG patients were compared to a control group to investigate the role of certain demographic, systemic and ocular factors. Risk factor analysis identified old age(> 60 years) (OR = 7.2, 95% CI = 4.4 - 11.7), geographical area (Western Cape, OR =2.5, 95% CI = 1.7 - 3.9), systolic hypertension (OR = 2.2, 95% CI = 1.3 - 3.7), diastolic perfusion pressure (< 40 mmHg, OR = 12.9, 95% CI = 4.2 - 52.9), myopia (OR = 2.7, 95% CI = 1.7 - 4.4) and elevated IOP (21 - 30 mmHg, OR = 12.6, 95% CI = 6.4 - 25.0) as significant risk factors. The effectiveness of employing certain blood pressure (BP) and intraocular pressure (TOP) variables as screening tools for glaucoma was evaluated. The systolic BP/IOP ratio was the most valid of the four tests evaluated (sensitivity = 66.0%, specificity = 98.2%, phi coefficient = 0.72). The study recommends that glaucoma screening programmes need to be developed which include sphygmomanometry as part of a battery of tests, and these programmes be targeted specifically at high risk populations (elderly, hypertensives). Further epidemiological studies are required which investigate reasons for the geographical differences found with respect to glaucoma prevalence.

Investigations of novel cell transplantation-based therapies for glaucoma

Johnson, Thomas Vincent January 2010 (has links)
No description available.

Characterization of NG2+ macrophage in glaucoma : an investigation focusing on its origin and potential roles in ischemic retina

Feng, Qian, 馮茜 January 2014 (has links)
Macrophage manipulation as immunomodulatory intervention in glaucoma, a leading cause to blindness characterized by retinal ganglion cell (RGC) loss, has been proposed as a promising strategy to protect RGCs from dying. Three types of macrophage in damaged retinas, microglia-derived macrophage, monocyte-derived macrophage and perivascular macrophage, together consist a highly heterogeneous population with both beneficial and detrimental functions partly resulted from their distinct origins. NG2 (Nerve/glial antigen 2) positive macrophage, a subtype of macrophage, has been considered to fulfill specific functions with neuroprotective and neurogenic potentials. Whether NG2+ macrophage can be a possible target for treatment in glaucoma is unknown. Basic information of this subtype of macrophage in ischemic retinas of a mouse glaucomatous model called acute ocular hypertension (AOH) model was obtained in this study to answer three questions. First, do NG2+ macrophage exist in mouse retina, if so, what do they like? In normal mouse retinas, NG2+ macrophage did not exist. After AOH, NG2 could be induced on macrophage. And they are unevenly distributed in the whole retina while reside in the ganglion cell layer, inner plexiform layer or inner nuclear layer. Moreover, NG2+ macrophage all contained two nuclei with typical amoeboid-like morphologies of macrophage in activation state except the rounded type. Secondly, are they associated with the surrounding cells, if so, how? Close association of RGCs and Müller cells with NG2+ macrophage was found due to their co-localization. To know how they functioned, potential roles regarding its proliferating and phagocytic abilities were revealed by its co-localization with proliferating and phagocytic markers. However, unlike NG2+ macrophage in ischemic brain, NG2+ macrophage in ischemic retina did not express neurotrophic factors while some of them were found to express interlukin-10, an anti-inflammatory cytokine. Possible neurogenic potential was also observed by its co-localization with Nestin, a neural stem cell marker. Thirdly, where do they come from? To know their origins, bone marrow chimeras combined with specific markers were used to distinguish microglia-derived macrophage, monocyte-derived macrophage and perivascular macrophage. And it was found that majority of NG2+ macrophage was originated from resident microglia, rather than monocyte-derived macrophage or perivascular macrophage. Taken together, the present study showed the basic profile of a subtype of macrophage in a mouse model of glaucoma, more accurately, NG2+ macrophage in AOH mouse retinas. NG2 expression was induced mostly in resident microglia in AOH retina as a proliferating population with phagocytic, anti-inflammatory functions, and possible neurogenic potentials. Therefore, NG2+ macrophage may be a potential candidate target for treatment of glaucoma. / published_or_final_version / Anatomy / Doctoral / Doctor of Philosophy

Oculokinetic perimetry for the detection of glaucomatous visual field loss

Fenerty, Cecilia Helen January 2000 (has links)
No description available.

Chiral liquid chromatography of metipranolol and its degradation products

Sharma, Satish Chander January 1994 (has links)
No description available.

Resolution perimetry : theory, development and application

Ennis, Fergal Anthony January 2001 (has links)
No description available.

Corticosteroids, 11β-hydroxysteroid dehydrogenase isozymes and the human eye

Rauz, Saaeha January 2002 (has links)
No description available.

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