In this thesis, we suggest a goodness-ofit test for semi-parametric copula models. We extended the pseudo in-and-out-sample (PIOS) test proposed in [17], which is based on the PIOS test in [28]. The PIOS test is constructed by comparing the pseudo "in-sample" likelihood and pseudo "out-of-sample" likelihood. Our contribution is twoold. First, we use the approximate test statistics instead of the exact test statistics to alleviate the computational burden of calculating the test statistics. Secondly, we propose a parametric bootstrap procedure to approximate the distribution of the test statistic. Unlike the nonparametric bootstrap which resamples from the original data, the parametric procedure resamples the data from the copula model under the null hypothesis. We conduct simulation studies to investigate the performance of the approximate test statistic and parametric bootstrap. The results show that the parametric bootstrap presents higher test power with a well-controlled type I error compared to the nonparametric bootstrap.

In certain areas such as Pharmacokinetic(PK) and Pharmacodynamic(PD), the hazard rate function, denoted by ??, plays a central role in modeling the instantaneous risk of failure time data. In the context of assessing the appropriateness of a given parametric hazard rate model, Huh and Hutmacher [22] showed that their hazard-based visual predictive check is as good as a visual predictive check based on the survival function. Even though Huh and Hutmacher’s visual method is simple to implement and interpret, the final decision reached there depends on the personal experience of the user. In this thesis, our primary aim is to develop nonparametric goodness-ofit tests for hazard rate functions to help bring objectivity in hazard rate model selections or to augment subjective procedures like Huh and Hutmacher’s visual predictive check. Toward that aim two nonparametric goodnessofit (g-o) test statistics are proposed and they are referred to as chi-square g-o test and kernel-based nonparametric goodness-ofit test for hazard rate functions, respectively. On one hand, the asymptotic distribution of the chi-square goodness-ofit test for hazard rate functions is derived under the null hypothesis ??0 : ??(??) = ??0(??) ??? ? R + as well as under the fixed alternative hypothesis ??1 : ??(??) = ??1(??) ??? ? R +. The results as expected are asymptotically similar to those of the usual Pearson chi-square test. That is, under the null hypothesis the proposed test converges to a chi-square distribution and under the fixed alternative hypothesis it converges to a non-central chi-square distribution. On the other hand, we showed that the power properties of the kernel-based nonparametric goodness-ofit test for hazard rate functions are equivalent to those of the Bickel and Rosenblatt test, meaning the proposed kernel-based nonparametric goodness-ofit test can detect alternatives converging to the null at the rate of ???? , ?? < 1/2, where ?? is the sample size. Unlike the latter, the convergence rate of the kernel-base nonparametric g-o test is much greater; that is, one does not need a very large sample size for able to use the asymptotic distribution of the test in practice.