Diss. - Brno. / Third page folded. Includes 26 beautiful engraved plates. Text in Latin and German.

Thesis (M.D.)--Faculté De Médecine De Paris, 1853. / Includes bibliographical references.

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Dissertation thesis submitted in partial compliance with the requirements for the Master's degree in Technology: Homoeopathy, Technikon Natal, 2001. / The aim of this placebo-controlled study was to investigate the homoeopathic simillimum treatment of acute arthritis in primary gout in terms of the illness intrusiveness scale, blood uric acid levels using the uricase conversion method as well as the Acupulse Homeostat machine. For this study 30 patients suffering from primary gout were required. The patients were obtained by advertising in local newspapers and at retirement homes. Patients were included in the study if they presented with six of the seven criteria taken from the American Rheumatism Association's criteria for acute arthritis of primary gout. The patients were randomly divided into two groups: a treatment group, receiving homoeopathic simillimum treatment and a control group, receiving a placebo. Two follow-up consultations were scheduled at two week intervals. Data was obtained by means of a questionnaire (completed by the patient), readings from the Acupulse homeostat machine and a blood uric acid test. This data was collected at all three consultations. Data entry and analysis was done using the SPSS statistical package. Due to the small sample size, data obtained from the questionnaire was statistically analyzed using non-parametric methods. The Mann-Whitney Unpaired Test was done to compare the treatment and placebo groups. Results showed that there was no significant difference between the groups. The Wilcoxon's Signed Rank Test was done to compare data within groups. The only significant difference was found within the treatment group between the first and second consultations as well as the first and third consultations. There was significant improvement with regard to active recreation. The tests were performed at a = 5% level of significance. Data obtained from the Acupulse Homeostat machine as well as the blood tests were analyzed using parametric tests because of the fact that they were continuous variables (regardless of the small sample size per group). In the case of both variables, comparison between the treatment and placebo group was made using the Two-Sample Paired T-Test and comparison within groups / M

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一.背景 痛风性关节炎，属于中医“痹证”“白虎历节风”“痛风”范畴。是以高尿酸血症为生化基础，继发尿酸盐结晶沉积、关节损害、结石形成所致的急慢性关节炎，表现为关节红、肿，疼如刀绞，痛剧难忍，亦可自行缓解，常发作无常，来去如风，故名痛风，是痛风病的中、后期阶段。严重者可造成骨质破坏、关节畸形。 本病受遗传、环境和饮食习惯的影响，患病率逐年增加。现代医学治疗本病，急性期以控制症状，减轻痛苦；缓解期以降低高尿酸血症为目标，尚无根治方法；况且所用药物均有较大的毒副反应，使本病的治疗处于窘境。中医中“痛风”之名始於金元，由朱丹溪首先提出，并设专篇论述，其在〈格致余论－痛风〉中指出“痛风者，四肢百节走痛，书中谓之白虎历节风证是也”“大率因血受热，已自沸腾，其后或涉冷水，或立湿地，或扇风取凉，或卧地当风，寒凉外搏，热血得寒，污浊凝瑟所以作痛，夜则痛甚，行于阴也”。其发病以脾肾两虚为本，湿、 热、毒、为标，热毒重可生湿，湿邪盛能化热，内毒流窜经络，攻注骨节，着于经脉，终致湿热毒交互为患，证属正虚邪实。近年来中医药对痛风研究逐渐深入，主要为中药汤剂的研究较为广泛，关于针灸、推拿、拔罐等中医传统特色治疗研究逐步开展，并取得可喜成绩。 二．目的 本次研究拟通过对现有关于痛风性关节炎中医手段治疗的临床研究类文献和实、验研究类文献的搜集、整理、分析，从而对痛风性关节炎中医治疗手段的临床有效率进行统计，并对痛风性关节炎中医治疗手段的改进与发展进行探讨。 三．万法 本論文文献资料来源：中国期刊全文数据库（CNKI）。通过对中国期刊全文数据庫库（CNKI）进行标准检索，方法为：计算机检索2005年－2015年国内外关于痛风性关节炎的中医治疗文献，搜素关键宇：痛风性关节，并包含中医、中药、针刺 、针灸， gout 、gouty arthritis。 经过文章检索方法的纳入与排除，得到所研究的文献。 四,結果 搜索中医治疗痛风性关节炎综遮类文献356篇；中药类治疗文献493篇，其中中药内用临床研究类文献317篇、中药内用实验研究类文献176 篇、中药外敷类研究文献79篇；针刺、针灸类治疗研究文献183篇，排除重复19篇，剩余共计164篇。经纳入和排除后，共得可用文献145篇，其中痛风性关节炎证候分型、辩证论治类21篇，中药、针刺等各法临床类研究文献83篇，实验类研究文献4l篇。 在文献分析过程中得出结果：1.痛风性关节炎的证型为：湿热蕴结型、淤热阻滞型、痰浊阻滞型、肺气虚弱型、肝肾阴虚型等。2. 病情分期为：急性期、静止期、慢性期。3.（统计排位前三）中药内用常用方剂为：四妙九、上中下痛风汤、二陈汤；常用中药为：薏苡仁、黄柏、牛膝；常用药物类为：通络止痛类、清热燥湿解毒类、利湿化浊类；常用药对为：茯苓与薏苡仁、苍术与黄柏、山栀与黄柏；常用针刺术穴位：曲池、血海、三阴交。 研究文献中所有中医临床治疗方法均对痛风性失节炎有效，作用率100% 。并无毒、副作用。 五, 结论 中医治疗对于痛风性关节炎有良好的综合性治疗效果，强于口服西药。

M.Tech. / This research was conducted to determine the effect of homoeopathic treatment on acute gout patients. Putterman (1994) conducted a research study on the effect of the homoeopathic remedy Colchicum autumnale in gout, and found partial improvement in the clinical picture of gout. No research has been conducted in South Africa on the efficacy of homoeopathic medicines in acute gout patients. This study focused on the homoeopathic Law of Similars, where a single most similar homoeopathic remedy was chosen according to the unique characteristic symptoms displayed by each participant suffering with acute gout. This was a qualitative study that used ten subjects who presented within five days of acute gout and participated in the fifteen-day study period. Participants that complied with the American College of Rheumatology (formerly American Rheumatism Association, ACR) criteria for gout were selected. Serum uric acid tests were taken on day 0 and day 6 to assess hyperuricemia. On day 0 a thorough case history and examination was taken followed by administration of the indicated remedy. Treatment efficacy was evaluated on day 1, 3 and 6, based on daily subjective impression of participant involvement, objective analysis and comparative analysis of serum uric acid. Re-examination for relapses or rebound attacks followed on day 15. In a study using allopathic remedies in acute gout, resolution of all acute gout symptoms occurred at an average of 8 days using indomethacin and 7 days using triamcinolone (Alloway et. al., 1993). In this study using homoeopathic similimum treatment, resolution of all acute gout symptoms occurred at an average of 6 days. One episode of a rebound gout attack occurred and serum uric acid decreased in 80% of patients. Homoeopathic similimum prescribing is an effective alternative treatment for acute gout. Although more research is required, the preliminary findings of this study suggest that the correct homoeopathic similimum treatment is an effective treatment for the symptoms of acute gout.

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Thesis (M.Sc.)--Victoria University of Wellington, 2009. / "Malaghan Institute of Medical Research." Includes bibliographical references.