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Chapter 1: Reaction of benzoaldehyde with wittig agents or isophone to build up conjugate carbon chain, then combined with electron acceptor to furnished the chromophores. The charge-transfer chromophores, which have the first molecular hyperpolarizability

Lyconadin A is a pentacyclic Lycopodium alkaloid isolated from the club moss Lycopodium companatum with anticancer activity. Our approach sought to incorporate a 7-exo–6-exo acyl radical cyclization cascade to access the bicyclo[5.4.0]undecane framework of lyconadin A. Our studies created methodology for the synthesis of 5-alkyl and 3,5-dialkyl-6-carbomethoxy-2-pyridones and sterically demanding epoxide substrates. These epoxide substrates underwent an unanticipated Payne rearrangement.Cranomycin is a potent antibiotic with antiprotozoal activity. Structurally it is a cyclopentane ring system with substitution at each carbon in the ring. Another interesting structural aspect is the existence of three contiguous quaternary stereocenters including two tertiary alcohols and a tert-alkylamine. Our strategy led to the development of a highly diastereoselective synthesis of vicinal tertiary diol systems. We have successfully synthesized the cyclopentenone system shown above, from which we hope to assemble cranomycin.

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