The cost of feeding has been pointed out as the most trascendet investment inside a guinea-pig production. The present work carries out with the purpose to determine and to quantify feeding costs, total costs of production and profitability of Tamborada and MEJOCUY guinea-pig populations. In the stage of suckling period, breed and gestation, experimental station and field. The result of feeding cost was 0.05 and 0.03 $US in suckling period (14 days) for Tamborada and MEJOCUY population, in breeding (42 days) it was 0.14 $US in both populations and in gestation (67 days), it was 0.42 and 0.40 $US. In field for breeding it was 0.07 $US and in gestation it was 0.11 $US. According to the Feeding cost, the MEJOCUY population has bigger technical profitability than Tamborada, the results show a positive and high utility that indicates that the upbringing of guinea pigs is profitable.