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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 41 to 50 of 423 (0.03 seconds)| 41 |
Stabilization of eptifibatide by cosolventsZhao, Luwei January 2000 (has links)
Eptifibatide is a potent and highly specific inhibitor of platelet receptor glycoprotein IIb/IIIa and is indicated in the treatment of acute coronary syndrome. The commercial product Integrilin® (eptifibatide) Injection requires a cold/refrigerator storage condition. In an effort to improve the drug stability for room temperature storage and transportation, this study proposed a semi-aqueous formulation that contains 2 mg/ml dose, 10% ethanol, 40% propylene glycol and 50% 0.025 M citrate buffer. A carefully designed stability study was conducted in the pH range 4.25-6.25 under accelerated temperatures: 48°C, 60°C, 72.5°C. The results indicate that the proposed semi-aqueous vehicles greatly increased eptifibatide stability in comparison with aqueous vehicles. The pH-rate profiles of eptifibatide are V-shaped with the curves for semi-aqueous vehicles lower all over the test pH range. The pH of drug maximum stability is 5.25 in the aqueous vehicle, and it is shifted to 5.75 in the semi-aqueous vehicle. Studies indicate that eptifibatide degradation may involve a few different mechanisms: the specific acid catalyzed hydrolysis which is dominant in the acidic region, and a pH-dependent oxidation which is likely to be dominant in the basic region of the test pH range. The predicted drug shelf-life T90 at 25°C shows that an almost 2-fold increase can be achieved by formulating eptifibatide in the semi-aqueous vehicle, which is 60 months at its maximum stability pH 5.75 as opposed to the 33 months in the aqueous vehicle at its maximum stability pH 5.25.
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BIOSYNTHESIS OF L-AZETIDINE-2-CARBOXYLIC ACID IN ACTINOPLANES FERRUGINEUSLEE, KANG MAN. January 1985 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
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ANALYTICAL AND METABOLIC STUDIES OF MITOTANE AND ITS ANALOGUESRUANGWISES, NONGLUCK. January 1990 (has links)
Thesis (Ph. D.)--University OF MICHIGAN. / CHAIRMAN: JOSEPH E. SINSHEIMER.
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QUANTITATIVE MECHANISTIC STUDIES OF ZONAL TRANSPORT AND METABOLISM IN THE HEPATIC ACINUSCHEN, ELINOR HUEI-LING. January 1982 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
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SELECTED STUDIES ON THE BARRIER PROPERTIES OF SKINGOVIL, SHARAD KUMAR. January 1984 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
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ESTERASE HYDROLYSIS OF AN HOMOLOGOUS SERIES OF PABA ESTERS IN HAIRLESS MOUSE AND HUMAN SKIN HOMOGENATESWITHAM, SANDRA LYNN CHANEY. January 1989 (has links)
Thesis (Ph. D.)--University OF MICHIGAN. / CO-CHAIRMEN: JENNIFER B. DRESSMAN; GORDON L. FLYNN.
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INVESTIGATION INTO DRUG AND DRUG ANALOGS TRANSPORTED BY THE PEPTIDE CARRIER SYSTEM: INTESTINAL ABSORPTION OF CAPTOPRIL AND OF PEPTIDYL DERIVATIVES OF METHYLDOPAHU, MING. January 1988 (has links)
Thesis (Ph. D.)--University OF MICHIGAN. / CHAIRMAN: GORDON L. AMIDON.
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| 48 |
THE MECHANISM OF ACTION OF SOLUTION FLUORIDE UPON THE DEMINERALIZATION RATE OF ENAMELMIR, NASIM AKHTAR, January 1967 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
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LIPOSOMES AS A POTENTIAL ORAL DRUG DELIVERY SYSTEMCHIANG, CHIA-MING. January 1900 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
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SOLID-STATE STUDIES ON THE POLYMORPHS OF METHYLPREDNISOLONEMUNSHI, MAYANK VIRENDRA. January 1973 (has links)
Thesis (Ph. D.)--University OF MICHIGAN.
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