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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Characterisation of regulatory T cells in HIV-infected adults in South Africa

Suchard, Melinda Shelley 13 October 2008 (has links)
ABSTRACT Regulatory T cells (Tregs) are CD4+ T lymphocytes that express the gene FOXP3 and suppress other cellular immune responses. Their role in HIV pathogenesis is uncertain. Regulatory T cell (Treg) levels were analysed in peripheral blood of HIV infected patients and controls in South Africa. Immunophenotypic analysis revealed significantly elevated levels of FOXP3 positive Tregs in HIV infected patients (median 6.8%) compared with controls (median 3.7%). Treg levels were inversely correlated with CD4+ T cell count. FOXP3 mRNA expression was dependent on choice of reference gene (GAPDH or 18sRNA) and did not correlate with FOXP3 protein expression analysed flow cytometrically. These findings illustrate that Tregs are elevated in the peripheral blood of patients with late stage HIV disease and suggest a role for Tregs in the clinical immune suppression seen in these patients. Tregs may prove to be useful therapeutic targets for intervention or as a prognostic monitoring tool.

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