This qualitative study considers the notion of evidence-based practice (EBP) and specifically what can be learnt from practice wisdom (PW). It is centres on a third sector organisation working with vulnerable young people. The study uses methods of observation, semi-structured interviews and focus groups, to establish the core components of effective practice. Findings reveal the need to adapt programmes to make them culturally relevant and that four specific approaches are needed for positive outcomes regardless of context. These are building effective working alliances; establishing clear and consistent boundaries with structure and discipline; motivating clients who are not always ready for change; and building hope and aspiration in young people that shows them how their futures might be different. Consideration is given to the ethical imperative to do no harm and findings are presented as to why this might happen based on practice experience. Theoretical fidelity is discussed and findings are critiqued in order to establish why these practice components work, how to avoid causing harm and how such practice may be improved further. It is concluded that although EBP cannot be achieved by an organisation alone due to wider client factors and policy maker decisions, there are core components identifiable through PW that encourage effective practice with vulnerable people.