Diss. (sammanfattning) Uppsala : Uppsala universitet, 2009. / Härtill 5 uppsatser.

Thesis (M.S.)--Montana State University--Bozeman, 2004. / Typescript. Chairperson, Graduate Committee: Alexander V. Zale. Includes bibliographical references (leaves 54-60).

Thesis (M.S. in Mechanical Engineering)--Vanderbilt University, Dec. 2004. / Title from title screen. Includes bibliographical references.

Thesis (M.S.)--University of Wisconsin--Madison, 1970. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Thesis (Ph. D.)--Ohio State University, 2006. / Title from first page of PDF file. Includes bibliographical references (p. 114-129).

Thesis (Ph. D.)--Ohio State University, 2007. / Full text release at OhioLINK's ETD Center delayed at author's request

Thesis (Ph. D.)--University of Washington, 2006. / Vita. Includes bibliographical references (leaves 213-235).

Submitted by ROBERTO PAULO CORREIA DE ARAÚJO (ppgorgsistem@ufba.br) on 2016-08-30T16:56:46Z No. of bitstreams: 1 Máilla Rebouças Viana dissertação pdf.pdf: 1628670 bytes, checksum: 0f14f7eed7546953dae78ed1447bf742 (MD5) / Made available in DSpace on 2016-08-30T16:56:46Z (GMT). No. of bitstreams: 1 Máilla Rebouças Viana dissertação pdf.pdf: 1628670 bytes, checksum: 0f14f7eed7546953dae78ed1447bf742 (MD5) / INTRODUÇÃO: A Leucemia Mielóide Crônica (LMC) é uma doença mieloproliferativa crônica caracterizada pela presença do cromossomo Philadelphia (Ph). Este cromossomo, observado por técnicas citogenéticas convencionais, é resultante da translocação t(9;22)(q34;q11) que justapõe o rearranjo BCR-ABL, observado por técnicas moleculares. A detecção desse cromossomo ou do rearranjo é fundamental, pois não somente contribui para o diagnóstico, mas também interfere no acompanhamento e no sucesso da terapia utilizada. O rearranjo BCR-ABL possui atividade tirosina quinase elevada, o que levou ao desenvolvimento de novos fármacos inibidores desta ação, conhecidos como inibidores de tirosino quinase (TKI). OBJETIVO: O objetivo deste estudo foi demonstrar a importância da utilização da técnica de citogenética molecular (Fluorescent in situ Hybridization - FISH) aliada a citogenética clássica no monitoramento de pacientes com LMC em terapia com TKI, no Estado da Bahia. METODOLOGIA: Foram analisadas amostras de medula óssea de 20 pacientes com LMC, em tratamento com TKI, encaminhados ao Serviço de Genética Médica do Hospital Universitário Prof. Edgard Santos, utilizando as técnicas de citogenética clássica e FISH. RESULTADOS: Resultados obtidos demonstraram que o cromossomo Ph foi observado em 15%, com a citogenética clássica, e o rearranjo BCR-ABL em 90%, com a citogenética molecular. Outro ponto importante foi que em alguns casos o resultado só foi possível com a técnica molecular, pois a técnica convencional não foi suficiente pela impossibilidade na análise das metáfases, devido a fatores como falta de crescimento celular. CONCLUSÃO: A técnica de FISH demonstrou maior sensibilidade nos casos que a citogenética clássica não detectou o cromossomo Ph, entretanto as duas técnicas foram fundamentais para os resultados obtidos por apresentarem vantagens e desvantagens em relação à outra e, portanto, devem ser usadas de maneira complementar no monitoramento de pacientes com LMC em tratamento com TKI.

The constant mutability of cultures as they meet and mix provides an ongoing laboratory in which to explore human dynamics. In this dissertation, I analyze the process and results of one indigenous-colonial encounter in Dutch Indonesia, using archaeological evidence from Banten, Java that illuminates interactions between Bantenese elites and Dutch East India Company (VOC) soldiers in the 17th to early 19th century. Banten, a global trade center and the focal point of Dutch expansion in Asia, had a cosmopolitan and multinational society of long standing, already apparent when the Dutch arrived in 1596. My research shows that a kind of "reverse" colonialism occurred here. Bantenese cultural influences penetrated more deeply into Dutch culture than the other way around, so that colonial Dutch culture took on a new, hybridized identity. Utensils and vessels necessary for preparing and serving meals from excavations in the indigenous Sultan's Surosowan Palace, its surrounding Fort Diamond manned by VOC soldiers, and the Dutch headquarters at Fort Speelwijk provide the evidence. Petrographic and archaeological study indicate that the Dutch used locally produced Bantenese-style cooking vessels and lids, rather than import European tripod pots to accommodate their traditional open-fire cooking. Local Bantenese continued to use cooking stoves without tripod vessels, maintaining their culinary habits. VOC archives revealed a change in Dutch staple food from bread to rice. Hired male cooks and local women who prepared home meals (as wives and concubines) acted as cultural conduits, while vibrant local manufacturing and trade made local goods readily available. Thus Dutch cooking became hybridized with locally available vessels and ingredients. The Banten results differed from the Dutch Cape Colony in South Africa but were similar to the Dejima trading post in Japan where the Dutch relied on local products. I conclude that proximity and daily interactions with the host society were crucial for shaping Dutch responses to the new environments and creating hybrid culture, instead of replicating their homeland. This study places Banten on the global map of cross-cultural interactions and colonial discourse; I hope to stimulate other researchers to test my hypotheses and build on these interpretations. / 2016-12-31T00:00:00Z

This thesis is focused on genetic evaluetion of Cervus nippon komplex and particulary on Cervus nippon pseudaxi and cervus nippon taiouanus kept i European ex situ instituion