John Harbison's status as a significant contemporary American composer is confirmed by his numerous appointments, honorary degrees, and awards. He is the recipient of nearly every major composition award, with works performed by major orchestras and in important opera houses spanning the world. This paper examines in detail Harbison's most acclaimed choral work, the 1987 Pulitzer Prize-winning The Flight into Egypt. This study of the score is a "conductor's analysis," offering a musical guide for the conductor who seeks to perform this work. To provide a context for the discussion, Chapter 1 offers a brief biographical sketch of Harbison's life and career. Chapter 2 provides the analysis of the work and includes a history from commission to premier, a discussion of Harbison's selection of text, and an examination of the pitch organization which informs the piece. In Chapter 3, I present important rehearsal and performance implications to consider when undertaking a performance of the work. Interviews with two well-regarded conductors who have performed The Flight into Egypt, David Hoose and Patrick Gardner, and the composer himself, provide valuable insight into this discourse.