Thesis (Ph. D.)--Virginia Commonwealth University, 2007. / Prepared for: Dept. of Physical Therapy. Bibliography: leaves 127 - 142 . Also available online via the Internet.

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2004. / Härtill 5 uppsatser.

Thesis (Ph. D.)--University of Washington, 2005. / Vita. Includes bibliographical references (leaves 189-196).

<p> The study concerns how human observers judge the relative position of successively presented points of light in an otherwise dark field. In particular, the possible role of involuntary head movements and binocular/monocular viewing conditions is considered. The data are analysed in terms of a mathematical model of the perceptual process which deals with short term memory for visual position. Contrary to previous suggestions in the literature, neither of the viewing variables proved to have a significant effect. In addition, the results provide a strong test of the theoretical model which appears to confirm the model's validity. The results of this study are shown to suggest a particular direction for future experimentation.</p> / Thesis / Master of Arts (MA)

It has been hypothesized that head-unrestrained gaze shifts are controlled by an error signal produced by a feedback loop. It has also been hypothesized that the superior colliculus (SC) is within this feedback loop. If the feedback-to-SC hypothesis is valid, an unexpected mid-flight perturbation in gaze trajectory should be quickly followed by a concurrent change in the discharges of collicular saccade-related neurons. To verify this prediction experimentally, primate head movements were unexpectedly and briefly halted during head-unrestrained gaze shifts in the dark. Perturbed gaze shifts were composed of first a gaze saccade made when the head was immobilized by the head-brake, followed by a period where gaze was immobile, called a gaze plateau. The latter was composed of an initial period when the eyes and head were immobile, followed by a period wherein the head was released and the eyes counter-rotated to stabilize gaze. The plateau ended with a corrective gaze saccade to the goal location. In perturbed gaze shifts, there was widely distributed activity on the SC map during gaze plateaus, and there was no evidence that the initial motor program was aborted; the corrective gaze saccades were not "fresh" small stand-alone movements. Cells on the SC map responded at short latencies to head accelerations and associated gaze shift perturbations and carried a gaze position error (GPE = final - instantaneous gaze position) signal. As a large gaze shift progressed there was a caudo-rostral moving hill of activity on the SC map that encoded, not instantaneous veridical GPE, but a filtered version of it (time constant 100ms). Recordings from both the motor map and the so-called "fixation zone" in the rostral SC during perturbed head-unrestrained gaze shifts reveal gaze feedback control and a gaze feedback signal to the SC. However, these results do not prove that the SC is within the online gaze feedback loop, only that such a loop exists and that the collicular map is informed about its calculations.

Diss. (sammanfattning) Umeå : Umeå universitet, 2008. / Härtill 5 uppsatser.

Thesis (Ph. D.)--University of Washington, 1999. / Vita. Includes bibliographical references (leaves 114-122).

Since its inception around 1975, Positron Emission Tomography (PET) has proved to be an important tool in medical research as it allows imaging of the brain function in vivo with high sensitivity. It has been widely used in clinical dementia research with [18F]2-Fluoro-2-Deoxy-D-Glucose (FDG) and amyloid tracers as imaging biomarkers in Alzheimer's Disease (AD). The high resolution offered by modern scanner technology has the potential to provide new insight into the interaction of structural and functional changes in AD. However, the high resolution of PET is currently limited by movement and resolution (even for high resolution dedicated brain PET scanner) which results in partial volume effects, the undersampling of activity within small structures. A modified frame-by-frame (FBF) realignment algorithm has been developed that uses estimates of the centroid of activity within the brain to detect movement and subsequently reframe data to correct for intra-frame movement. The ability of the centroid to detect motion was assessed and the added benefit of reframing data for real clinical scans with patient motion was evaluated through comparison with existing FBF algorithms. Visual qualitative analysis on 6 FDG PET scans from 4 blinded observers demonstrated notable improvements (ANOVA with Tukey test, p < 0.001) and time-activity curves were found to deliver biologically more plausible activity concentrations. A new method for Partial Volume Correction (PVC) is also proposed, PARtially-Segmented Lucy-Richardson (PARSLR),that combines the strength of image based deconvolution approach of the Lucy-Richardson (LR) Iterative Deconvolution Algorithm with a partial segmentation of homogenous regions. Such an approach is of value where reliable segmentation is possible for part but not all of the image volume or sub-volume. Its superior performance with respect to region-based methods like Rousset or voxel-based methods like LR was successfully demonstrated via simulations and measured phantom data. The approach is of particular importance for studies with pathological abnormalities where complete and accurate segmentation across or with a sub-volume of the image volume is challenging and for regions of the brain containing heterogeneous structures which cannot be accurately segmented from co-registered images. The developed methods have been shown to recover radioactivity concentrations from small structures in the presence of motion and limited resolution with higher accuracy when compared to existing methods. It is expected that they will contribute significantly to future PET studies where accurate quantitation in small or atrophic brain structures is essential.

Moving the head-neck freely is an everyday task that a healthy person takes for granted. Such a simple movement, however, may be very challenging for individuals with neurological disorders such as amyotrophic lateral sclerosis. These individuals often do not have enough neck muscle strength to stabilize the head at the upright neutral or to move it in a controlled manner. Static braces are commonly prescribed to these patients. However, these braces often fix the head at a single configuration, which makes them uncomfortable to wear for an extended period of time. In this thesis, a robotic neck brace is developed. It accommodates three rotations and covers roughly 70% range of motion of the head-neck of a typical able-bodied adult. The hardware is lightweight (1.5 kilogram) and wearable, with a pair of pads and a soft band attached to the shoulders and the forehead, respectively. A parallel mechanism connecting the shoulder pads and the headband was designed to meet the empirical human movement data. This design choice is novel where the parasitic motion (translation of the head) was parameterized and optimized to address misalignment between the robot and the user's head. A user can control this neck brace to assist intended head-neck movement through input devices, including hand-held joysticks, keyboards, and eye-trackers. This provides a potential solution to remediate head drop. Additionally, this robotic brace is developed into a versatile platform to train and study head-neck movements. The robot was designed to be highly transparent to the user and features different force controllers. Therefore, it can be used to assess the free movement of the head-neck and mimic different interactions between a therapist and a patient. The modalities of this neck brace have been validated with different users. To the best of our knowledge, this robotic neck brace is the first in the literature to assist, train, and study head-neck movements.