Translation of national public health policy into local action is poorly understood. This thesis explores this issue using: (a) independent evaluation data of the government-funded Well Men’s Services Pilots Programme (WMS); and (b) an analytical framework derived from ‘rational’ health planning models; particularly the PRECEDE PROCEED (PP) model. A mixed-methods study was conducted, comprising: (i) a review of the health planning literature; (ii) an interpretative documentary analysis of policy documentation and local intervention plans; and (iii) a secondary analysis of 42 semi-structured interviews with local managers and professionals responsible for developing interventions in response to the policy. The research findings (ii&iii) were considered in light of this review. This thesis concluded that rationalist health planning approaches and frameworks are not sufficient to guide the implementation of public health policy to an effective conclusion, and has argued that there is a need to develop new ways of thinking about public health issues that have become ‘policy problems’ deemed in need of intervention and resolution. This new thinking needs to acknowledge the complex and contested nature of health problems. This include accepting: (1) that a range of different perspectives and interpretations of public health policy problems and associated notions of their solutions will reside amongst those individuals and organisations tasked with transforming policy into practice; (2) the inevitability of imperfect and contested evidence; (3) future uncertainties, and; (4) the existence of bureaucratic barriers that will constrain direct engagement of the intended beneficiaries, by policy implementers, in the process of developing interventions.

Dentists have traditionally been the sole gatekeepers to the delivery of primary care dental services. Direct Access, a measure that allows Dental Care Professionals to see patients without a referral from a Dentist, is a fundamental change to this long-standing principle. This thesis systematically explores the attitudes of stakeholders across the micro, meso and macro levels of dentistry towards Direct Access in two distinct health care systems, the Netherlands and the UK.Direct Access was introduced in the Netherlands in 2006 and subsequently introduced in the UK in 2013. This study uses a qualitative approach to explore the attitudes towards the introduction of Direct Access in both of these states. It presents the results of semi-structured interviews with 74 participants (individually or as part of a group) including Students, Dental Care Professionals and Dentists at the micro-level, representatives of Professional Associations, Insurers and Dental Schools at the meso-level and Policy Makers at the macro-level. The results of this study show a significant range of attitudes towards Direct Access, but reveal a degree of consensus within individual stakeholder groups towards the reform’s introduction and impact. Dental Care Professionals interpret the introduction of Direct Access as recognition of their capabilities and expect it to primarily benefit patients through access to care and expertise. Dentists were more likely to view the introduction of Direct Access in terms of competition or professional persecution, with the impacts considered from a professional or financial viewpoint. Policy Makers saw potential for Direct Access to realign dental workforces and services to contemporary care needs. Attitudes at the meso level demonstrated the greatest variety and were more influenced by the idiosyncrasies of their respective health care system. In comparing the attitudes towards Direct Access in the Netherlands and the UK there were several differences, such as in the support of the Direct Access by Principal Dentists, however many of these can be explained by differences in healthcare funding and the time difference between the two reforms. Despite these differences stakeholders in both states felt that while Direct Access had the potential to create significant impacts on a range of issues (including professional competition, patient access to care, the reduction of care costs to patients and the state, the redistribution of dental tasks and the remodelling of the dental workforce) it was unlikely to do so in either the Netherlands or the UK. Flaws in the Direct Access regulations, legal obstructions to crucial procedures and imbalances in street-level professional power were perceived to obstruct Direct Access. Rather than revolutionising dental services Direct Access has been implemented selectively in the interest of dental practices.

This thesis presents an empirical investigation into substance use, situational characteristics and sexual outcomes in men who have sex with men (MSM) motivated by the high rates of substance use in MSM; the association between substance use and sexual risk behaviours in MSM; the lack of specific theory addressing relationships between substance use, sexual interactions and social interactions between MSM; and the need for clearer understandings of encounter-level associations with sexual risk. Qualitative metasynthesis. This thesis begins with laying the methodological groundwork for a qualitative metasynthesis that theorises the relationship between substance use and social spaces in MSM, with a particular focus on sexual outcomes. The qualitative metasynthesis derives the key organising perspective of ‘littoral spaces’ in which substance use is associated with a pre-planned, though temporary, escape from the boundaries of everyday life to engage in maximal sensory exploration, including through sexual contact. <b>Systematic review of multiple-event analyses. The thesis then turns to a systematic review of previous quantitative multiple-event analyses examining associations between situational characteristics and sexual outcomes, which establishes the need for additional multiple-event analyses addressing specific substance use, location of sex, partner serodiscordance and partner type. Multiple-event analyses. Finally, informed by the qualitative metasynthesis and the systematic review of event-level analyses, this thesis presents multiple-event analyses addressing unprotected anal intercourse (UAI), pleasure and control as sexual outcomes in MSM in England. These analyses found that substance use was associated with greater odds of UAI and pleasure, but not with control, and that non-private locations of sex were associated with decreased odds of UAI and pleasure, but not control. Furthermore, there was sparse evidence of interactions between respondent and partner substance use and between respondent substance use and location of sex in associations with sexual outcomes. These analyses contribute to understandings of associations between substance use, situational characteristics and sexual risk behaviour by presenting the first known analyses on MSM in England and by examining sexual outcomes besides UAI.

Introduction: Cerebrovascular events are a major cause of mortality, disability and healthcare resource use. Despite this, there is a lack of reliable information on their costs and outcomes, particularly related to transient ischaemic attacks (TIA) and minor stroke. Such information is vital to inform decisions about local and national service provision, and to provide reliable estimates for use in cost-effectiveness analyses. Aims This thesis estimates the costs and outcomes of stroke and TIA using data from a population-based study undertaken in a population of over 91,000 individuals in Oxfordshire (the Oxford Vascular Study – OXVASC). In addition, the thesis aims to estimate the short-term cost-effectiveness of two secondary stroke prevention programmes evaluated in a study nested within OXVASC. Methods: Using multiple methods of case ascertainment, 1,282 patients were identified as having suffered a stroke or TIA, of which 1,199 (723 stroke and 476 TIA) patients consented to the study. Follow-up of patients took place at 1, 6, 12 and 24 months, with data collected on patients’ disability, medication usage, living arrangements, and quality of life. Healthcare resource use information was derived from hospital and primary care records, and priced using published unit costs. Findings: Stroke patients had higher case-fatality rates than TIA patients (15% vs. 1%; p<0.001), with 5-year life expectancy being one year longer for TIA patients. For stroke and TIA survivors, the risk of disability remained higher, at around 30% at each of the four follow-ups, than at baseline (17%; p<0.001 for all follow-ups). After standardising for age and gender, average quality of life for stroke and TIA patients combined was significantly lower than English population norms (p<0.001 for all follow-ups). However, when quality of life was compared to population norms by event type, quality of life differences between TIA patients and English population norms no longer remained statistically significant. Important predictors of quality of life included event severity, baseline disability and recurrent vascular events. Total costs were considerably higher 1-year after the initial stroke or TIA than for the year preceding it and, except for day cases, increases were observed for all resource-use categories. Five years after the index event, stroke patients incurred costs of £16,923 (95% CI: 15,149 to 18,858) per patient, significantly higher than those incurred by TIA patients, at £13,904 (95% CI: 11,488 to 16,657; p=0.019). In multivariate analyses, event severity was found to be a significant predictor of inpatient care resource use and costs, as were the presence of recurrent vascular events, especially stroke and coronary events. For non-hospitalised patients, results showed that urgent outpatient specialist assessment and treatment reduced the 90-day risk of fatal or disabling stroke (0.4% vs. 5%, p<0.001) compared with less urgent assessment and treatment. In terms of resource usage, patients who were assessed and treated urgently had lower recurrent stroke hospitalisation (2% vs. 8%; p=0.001), and reduced overall number of days in hospital (average reduction of 4 days; p=0.017). These reductions in hospital resource usage generated savings of £643 per patient assessed and treated urgently in an outpatient clinic (p=0.028). Conclusion: Despite the impact of stroke on death, disability and healthcare resource use, there is a lack of reliable information on costs and outcomes, especially for TIA and minor stroke. Through the use of a population-based study, the gold-standard study design when assessing the incidence and outcomes of TIA and stroke, this thesis provides healthcare decision makers and researchers with a wealth of data on the resource use patterns, costs and outcomes of TIA and stroke patients, and their main predictors.

This thesis is an ethnographic study of a little documented indigenous group, the Warekena people, who live on the Xié River in north-western Amazonia. Examining the mythic histories of the animate riverscape, my work offers an overview of the emergence of riverside dwelling: starting with a macro view of Xié river lifestyles, I explain how seasonal and distinguishing historic-mythic narratives tie in to wider idioms, and to experiences of social reproduction. I focus on reproductive processes and the perinatal period, highlighting methods used by Xié dwellers to nurture healthy, quality-conscious lifestyles, and I examine Xié aetiologies and pathologies. Mindfulness, or awareness, is viewed as a key component of good health. In this context, healthy childbirth is for the birthing mother an art form, a practice for which her total life experience has prepared her. Childbirth is ranked with such other painful experiences as snakebite, and both childbirth and snakebite are opportunities for personal growth. Infant care is seen through the lens of specific, hands-on techniques that promote mindful states in both the carer and the cared for. Mindfulness emerges as a heuristic device that allows us to scrutinize the Amerindian soul and body, also elucidating soul-loss in the ‘animist’ lived world. I argue that mindfulness is a core characteristic of the ‘cool’ hydrocentric and status-conscious lifestyles of Xié river dwellers, and that it defines what it means to be a person, the Xié way.