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The effects of aging and calorie restriction on whole-body and mitochondrial energeticsBevilacqua, Lisa January 2007 (has links)
It has been well documented that calorie restriction (CR) without malnutrition is an effective strategy to improve health and extend lifespan in a variety of species. The mechanisms underlying CR are unclear. We proposed that a reduction in proton leak-dependent respiration could play a central role in the action of CR by inhibiting reactive oxygen species (ROS) production. In support of this hypothesis, we found that CR resulted in a rapid and sustained reduction in both maximum leak-dependent respiration and ROS production in skeletal muscle mitochondria. We also demonstrated that CR appears to decrease ROS production by different mechanisms in the acute and chronic settings. To further pursue the mechanism governing these adaptations, we also examined the effect of acute CR in Uncoupling Protein-3 knockout mice (Ucp3-KO mice) and wild-type mice. We found that CR decreased skeletal muscle mitochondrial proton leak-dependent respiration in the wild-type, but not in the Ucp3-KO mice. The kinetic response of the proton leak reactions in Ucp3-KO mice subjected to CR indicated increased proton conductance, whereas no CR-induced differences were observed in wild-type mice. Further assessment of these differences suggest that alterations in proton leak with acute CR occur via a UCP3-independent mechanism, that to some extent, involves the Adenine Nucleotide Translocator (ANT). In summary, this dissertation demonstrates that the benefit of CR is mediated, at least in part, by a decrease in the production of ROS. However, the mechanisms underlying the action of CR are complex and involve several processes, including hypometabolism and mitochondrial proton leak. Further in vitro and in vivo research is warranted to better understand these mechanisms. Research in this area has important implications as it may lead to novel treatment strategies (e.g., nutraceuticals or pharmaceuticals) that could improve the quality of life for an increasing aging population.
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Les effets de l'addition de niacinamide lors d'une diète hyper-glucidique sur le taux de lactate sanguin à l'exercise.Mongeon, Jean R. January 1983 (has links)
No description available.
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Understanding cultural adherence and the use of traditional medicine in Waskaganish First NationTabib, Christine January 2011 (has links)
No description available.
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Identifying the extent to which diet quality and physical activity levels relate to obesity and insulin resistance in liyiyiu Aschii (Cree) adultsLazzinnaro, Robert January 2011 (has links)
No description available.
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Prevalence and correlates of food insecurity in Inuit communitiesHuet, Catherine January 2011 (has links)
No description available.
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Protein metabolism and insulin resistance in non-small cell lung cancer cachexiaWinter, Aaron January 2011 (has links)
No description available.
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A novel microencapsulated probiotic yogurt formulation for oral delivery in the suppression of intestinal tumorigenesis in «Apc»Min miceUrbanska, Aleksandra January 2009 (has links)
No description available.
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Relationships between tryptophan, diet, 5-hydroxytryptamine metabolism, 5-hydroxytryptamine function and behaviorTeff, Karen January 1988 (has links)
No description available.
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Accuracy of telephone-administered dietary recalls in a group of free-living elderly subjectsDubois, Sheila. January 1987 (has links)
No description available.
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Correlates and consequences of vitamin D status in older peopleBarake, Roula January 2010 (has links)
No description available.
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