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The Short-Time Target Cancellation (STTC) algorithm, developed as part of this dissertation research, is a “Cocktail Party Problem” processor that can boost speech intelligibility for a target talker from a specified “look” direction, while suppressing the intelligibility of competing talkers. The algorithm holds promise for both automatic speech recognition and assistive listening device applications. The STTC algorithm operates on a frame-by-frame basis, leverages the computational efficiency of the Fast Fourier Transform (FFT), and is designed to run in real time. Notably, performance in objective measures of speech intelligibility and sound source segregation is comparable to that of the Ideal Binary Mask (IBM) and Ideal Ratio Mask (IRM). Because the STTC algorithm computes a time-frequency mask that can be applied independently to both the left and right signals, binaural cues for spatial hearing, including Interaural Time Differences (ITDs), Interaural Level Differences (ILDs) and spectral cues, can be preserved in potential hearing aid applications. A minimalist design for a proposed STTC Assistive Listening Device (ALD), consisting of six microphones embedded in the frame of a pair of eyeglasses, is presented and evaluated using virtual room acoustics and both objective and behavioral measures. The results suggest that the proposed STTC ALD can provide a significant speech intelligibility benefit in complex auditory scenes comprised of multiple spatially separated talkers. / 2020-10-22T00:00:00Z