Cardiac rehabilitation has been shown to improve outcomes in patients with heart disease. Determining the effect cardiac rehabilitation (CR) has on the quality of life (QOL) of patients who have participated in a CR program is an important health outcome measure. The majority of QOL studies have focused primarily on younger patients with little attention devoted to the elderly. The purpose of this descriptive, comparative study was to determine whether participation or lack of participation in a CR program will affect the perceived QOL of elderly patients with coronary heart disease (CHD). The Sickness Impact Profile (SIP) was used to measure QOL of two groups, those who participated in CR and those who did not participate in CR. A demographic inventory was used to collect sociodemographic information. The mean SIP scores for the physical and psychosocial dimensions, as well as the overall SIP score revealed less dysfunction for the group that participated in CR thereby indicating a better quality of life for this group. However, other methods of data analysis were not statistically significant. Although the results of this study were not statistically significant, they may be of clinical significance as indicated by the mean SIP scores and the percent of non-overlap scores. Education of the older patient and the public about the beneficial effects of CR on QOL is a prime responsibility of nurse practitioners.

Abdominal obesity is a part of insulin resistance syndrome that is closely linked to increased risk of coronary artery disease (CAD). Because fat tissue acts as an endocrine target and source of hormone production, increased metabolism or production of chemical messengers in fat tissue may result in metabolic perturbations that contribute to occurrence and recurrence of coronary events. This dissertation research entails two separate approaches. The first study, a cross-sectional analysis, sought to determine whether serum cortisol responses to oral glucose loading are associated with abdominal obesity, non-esterified fatty acid (NEFA) suppression, and self-reported symptoms of depression in 26 non-diabetic coronary patients. We conclude that lower cortisol responses to oral glucose loading are associated with abdominal obesity, reduced NEFA suppression, and fewer symptoms of depression (P���0.028). Future prospective studies should determine whether psychosocial risk factors, such as depression and anxiety, increase cortisol production, whether increases in cortisol production act synergistically with a positive energy balance in the development of abdominal obesity, and whether increases in abdominal obesity lead to increases in cortisol metabolism and insulin resistance. C-reactive protein (CRP) is a marker of low-grade inflammation that is associated with increased risk for recurrent events in coronary patients. Fat tissue also secretes proinflammatory cytokines that stimulate hepatic production of CRP. Thus, the second study, an intervention study, sought to determine whether the first three months of cardiac rehabilitation could reduce serum concentrations of CRP and the proinflammatory cytokine, tumor necrosis factor-�� (TNF-��), in our non-diabetic coronary patients (N=26). Results from the intervention study showed significant reductions in serum CRP levels (P=0.012) that were associated with reductions in waist circumferences after cardiac rehabilitation (r=0.39, P=0.049). However, changes in serum TNF-�� levels after cardiac rehabilitation were nonsignificant (P=0.869). Thus, we conclude that cardiac rehabilitation may reduce the severity of low-grade inflammatory conditions, in part, through reductions in waist circumference in non-diabetic coronary patients. / Graduation date: 2001