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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Untersuchungen zur Regulation Motilitäts-assoziierter Gene in Helicobacter pylori

Niehus, Eike. January 2004 (has links)
Würzburg, Universiẗat, Diss., 2004. / Dateien im PDF-Format.

TraG-like transporter proteins of type IV secretion systems

Schröder, Gunnar. January 2003 (has links)
Berlin, Freie University, Diss., 2003. / Dateiformat: zip, Dateien im PDF-Format.

The role of DNA supercoiling in the coordinated regulation of gene expression in Helicobacter pylori

Ye, Fang. January 2004 (has links) (PDF)
Würzburg, University, Diss., 2004.

Clinical aspects in Helicobacter pylori infections

Houben, Martinus Henricus Maria Gerardus, January 2000 (has links)
Proefschrift Universiteit van Amsterdam. / Met lit. opg.

Helicobacter pylori : molecular insights into regulation of adhesion properties

Gideonsson, Pär January 2016 (has links)
Helicobacter pylori infects the human stomach and triggers an inflammatory response that damages the gastric tissue. This host-pathogen interplay has dire consequences as up to 20 % of infected individuals develop peptic ulcer disease or gastric cancer. Given that half of the world’s population is infected, the number of afflicted humans is staggering and also tells that H. pylori is extremely efficient in spreading and maintaining infection. To enable persistent infection many factors play a role, but one important feature of H. pylori is its impressive ability to adhere to the slimy gastric mucus layer and the underlying epithelial cells. This occurs mainly via the BabA and SabA proteins that bind ABO/Leb- and sLex/sLea-antigens. I have in my thesis studied how these two proteins are utilized and regulated. H. pylori transcription is in part controlled by two-component systems (TCSs) that use a sensor protein and a DNA-binding response regulator. We have studied how these systems control sabA and to some extent babA and indeed found a better map of how sabA and babA is regulated at the transcriptional level. We also found that variations in a polynucleotide T-tract located in the sabA promotor could fine-tune SabA expression/ sLex-binding. Thus we have exposed how strict regulation by TCSs combined with stochastic processes together shapes attachment in the bacterial population. As the buffering mucus layer is constantly exfoliated, placing H. pylori in bactericidal acid, we hypothesized that low pH should abrogate adhesion. SabA expression was indeed repressed in low pH, however BabA expression remained unaffected. The BabA/ Leb-binding was instead directly reversibly hampered by low pH and the degree of pH sensitivity was strain dependent and encoded in the BabA sequence. We believe that the pH dependent loss of binding is one key factor H. pylori utilizes to maintain persistent infection. BabA is divided in generalists that bind ABO antigens and specialists that only bind blood group (bg) O. We co-crystalized BabA bound to these receptors and established the structural basis for generalist vs. specialist discrimination. We furthermore found a disulfide-clasped loop (CL2) in the center of the binding domain crucial for binding. Breaking CL2 with N-Acetylcysteine (NAC) disrupted binding and H. pylori infection mice experiments revealed inflammatory reduction upon NAC-treatment. In sum, I have in my thesis dissected how H. pylori controls its adhesive abilities and how intrinsic properties in binding can be exploited for therapeutic purposes.

Helicobacter pylori colonization of the mouse gastric mucosa the Entner-Doudoroff pathway and development of a promoter-trapping system /

Wanken, Amy Elizabeth, January 2004 (has links)
Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xiii, 145 p.; also includes graphics (some col.). Includes abstract and vita. Advisor: Kathryn Eaton, Dept. of Veterinary Biosciences. Includes bibliographical references (p. 130-145).

Autoinducer-2 regulation of motility in Helicobacter pylori /

Rader, Bethany Anne, January 2006 (has links)
Thesis (Ph. D.)--University of Oregon, 2006. / Typescript. Includes vita and abstract. Includes bibliographical references (leaves 80 - 90). Also available for download via the World Wide Web; free to University of Oregon users.

Diagnostic en médecine générale

Ben Cheikh M'Hamed, Laurence. De Korwin, Jean-Dominique January 2003 (has links) (PDF)
Reproduction de : Thèse d'exercice : Médecine : Nancy 1 : 2003. / Titre provenant de l'écran-titre.

Inhibition of Helicobacter pylori by wild blueberry phenolics /

Garrett, June Kazumi, January 2009 (has links)
Thesis (M.S.) in Food Science and Human Nutrition--University of Maine, 2009. / Includes vita. Includes bibliographical references (leaves 45-48).

Die Rolle der Helicobacter pylori Infektion bei dyspeptischen Beschwerden und Hyperemesis gravidarum während der Schwangerschaft

Yasar, Zemine. January 2008 (has links)
Ulm, Univ., Diss., 2008.

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