Thesis (M.S.)--California Polytechnic State University, 2008. / "July 2008." "In partial fulfillment of the requirements for the degree [of] Master of Science in Engineering with a specialization in Biomedical Engineering." "Presented to the faculty of California Polytechnic State University, San Luis Obispo." Major professor: Trevor Cardinal, Ph.D. Includes bibliographical references (leaves 96-101). Also available on microfiche and online.

Thesis (Ph. D.)--West Virginia University, 2008. / Title from document title page. Document formatted into pages; contains xi, 140 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 117-128).

Thesis (M.S.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains xi, 80 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 66-68).

Thesis (M.S.)--University of Michigan, 1990.

Thesis (Ph. D.)--Ohio State University, 2003. / Title from first page of PDF file. Document formatted into pages; contains xvi, 246 p.; also contains graphics. Includes abstract and vita. Advisor: William W. Muir, Dept. of Veterinary Clinical Sciences. Includes bibliographical references (p. 229-246).

Thesis (M.S.)--University of Michigan, 1990.

Made available in DSpace on 2014-06-11T19:35:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-02-25Bitstream added on 2014-06-13T19:05:14Z : No. of bitstreams: 1 ramin_sl_dr_botfm.pdf: 6675562 bytes, checksum: e407c62c25fd29b384a5131a3ec35f20 (MD5) / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) / Foi realizado estudo experimental em coração isolado de coelhos, perfundido pelo método de Langendorff, para avaliar o efeito da cetamina S(+) associada à cardioplegia sangüínea, durante e na manutenção por 30 minutos de parada cardíaca, conforme critérios hemodinâmicos e morfológicos. Foram utilizados 50 coelhos da linhagem Norfolk-2000, pesando 1850 a 2350 g, divididos em três grupos de corações isolados: Grupo C (n=10) cardioplegia sangüínea; Grupo CC (n=10) cetamina S(+) associada à cardioplegia sangüínea e, Grupo PA (n=5) parada cardíaca anóxica. A função ventricular foi analisada pela técnica de balão intraventricular. Fragmentos de um único ventrículo esquerdo foram analisados como padrão de normalidade histopatológica. A análise estrutural e ultra-estrutural de fragmentos do ventrículo esquerdo após a parada cardíaca imediata por cardioplegia ou anóxica, seguida por período de manutenção. Foram obtidos os seguintes resultados: 1. Avaliação hemodinâmica. Pressão desenvolvida intraventricular (PDes): grupo C (76,39±17,69 mmHg e 62,08±32,13 mmHg) p <0,05; grupo CC (89,26±16,37 mmHg e 52,62±24,91 mmHg) p<0,05; grupo PA (77,96±12,67 mmHg e 60,81±29,68 mmHg), pré e pós-tratamento, respectivamente. Primeira derivada temporal da pressão ventricular na sua deflexão positiva (dP/dt+): grupo C (1236±181,15 mmHg/seg e 1150,20±174,44 mmHg/seg); grupo CC (1372,61±214.19 mmHg/seg e 1058,52±255,10 mmHg/seg) p<0,05; grupo PA (1252,39±99,76 mmHg/seg e 1115,10±73,07 mmHg/seg), pré e pós-tratamento, respectivamente. Primeira derivada temporal em sua deflexão negativa (dP/dt-): grupo C (856,01±132,26 mmHg/seg e 783,62±177,54 mmHg/seg); grupo CC (948,11±106,34 mmHg/seg e 760,28±219,37 mmHg/seg); grupo PA (911,02±74,53 mmHg/seg e 818,95±219,09 mmHg/seg), pré e pós-tratamento, respectivamente. 2. Avaliação morfológica. / An experimental study in isolated heart of rabbits, perfused by the Langendorff system, to evaluate the effect of S(+) ketamine associated with blood cardioplegia during and in the maintenance during 30 minutes of the cardiac arrest according to hemodynamic and morphological criteria. A total of 50 Norfolk-2000 rabbits, weighting 1850 to 2350 g, were divided into three groups of isolated hearts: blood cardioplegia-BC (n=10); S(+) ketamine associated with blood cardioplegia-K (n=10), and anoxic cardiac arrest-CA (n=5). The ventricular function was analyzed by the intra-ventricular balloon technique. The structural and ultrastructural analysis of fragments of the left ventricle after immediate cardiac arrest by cardioplegia or anoxic arrest, followed by maintenance period. The fragments of the left ventricle were analyzed as pattern of histopathological normality. The following results were obtained: 1. Hemodynamic evaluation. Intra-ventricular developed pressure (IVDP) was: group BC (76.39±17.69 mmHg and 62.08±32.13mmHg) p<0.05; group K (89.26±16.37mmHg and 52.62±24.91mmHg) p<0,05; group CA (77.96±12.67mmHg and 60.81±29.68mmHg), pre and posttreatment, respectively. First derivative of intraventricular pressure in its positive deflection (dP/dt+) was: group BC (1236±181.15 mmHg/sec and 1150.20±174.44 mmHg/seg); K (1372.61±214.19 mmHg/sec and 1058.52±255.10mmHg/seg) p<0.05; CA (1252.39±99.76 mmHg/sec and 1115.10±73.07 mmHg/sec), pre and posttreatment, respectively. First derivate pressure in its negative deflection (dP/dt-) was: group BC (856.01±132.26 mmHg/sec and 783.62±177.54 mmHg/sec); K (948.11±106.34 mmHg/sec and 760.28±219.37 mmHg/sec); CA (911.02±74.53 mmHg/sec and 818.95±219.09 mmHg/sec) pre and posttreatment, respectively. 2. Morphological evaluation.

Cerebral haemodynamic status defined as cerebral vasoreactivity to carbon dioxide and pressure autoregulatory response, have been shown to be affected after traumatic brain injury (TBI) and correlate with the neurological condition and clinical outcome. Therefore, it is important to have a reliable method to determine the cerebral haemodynamic status in brain-injured patients. Blood flow velocity (BFV) measurement by transcranial Doppler ultrasonography (TCD) has been shown to give accurate indication of changes in cerebral blood flow (CBF). Transient hyperaemic response (THR) test with TCD measurement to assess the BFV response of middle cerebral artery to a brief compression of the ipsilateral carotid artery, provides a simple method for repeated assessment of the cerebrovascular autoregulatory reserve in brain injured patients. However, the test has not been validated systematically against classical assessment tests using TCD and gold standard CBF measurement. / The aims of this thesis are (1) to validate the non-invasive TCD and its haemodynamic tests with a more involved gold standard CBF measurement using stable xenon-enhanced computerized tomography. (2) To correlate the cerebral haemodynamic abnormalities with the patterns of neurochemical disturbance detected by intracerebral microdialysis. (3) To investigate the possibility to reverse or minimized the cerebral haemodynamic abnormalities and metabolic derangement by treatment. (Abstract shortened by UMI.) / The goal of intensive care management for TBI is to provide them with a favourable physiological and metabolic environment for recovery of the injured-compromised cells. The development of clinical intracerebral microdialysis has enabled documentation of the metabolic derangement that provides more understanding of the mechanism of brain damage. Continuous measurement of both neurochemical and physiological parameters including CPP defined as mean arterial blood pressure (ABP) minus intracranial pressure, BFV and CBF, enables study of the relationship between metabolic events and physiologic changes. Clinical management of patients with TBI has emphasized on maintaining an optimal cerebral perfusion pressure (CPP). This critical CPP can then be defined by TCD, CBF as well as the metabolic measurements. / Ng Chi Ping. / "June 2005." / Adviser: Wai-sang Poon. / Source: Dissertation Abstracts International, Volume: 67-01, Section: B, page: 0122. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2005 / Includes bibliographical references (p. 147-154). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.

Exposure to hyperoxia has been shown to have detrimental effects on newborn hemodynamics and antioxidant activities in males. These effects are unknown in the newborn female, despite clinical data showing that in children undergoing surgery females have poorer outcomes. This thesis explored whether newborn females respond worse than males to hyperoxia, specifically in hemodynamics and antioxidant activity. Hemodynamic results showed continual decreases in DBP and MAP, increases in HR, decreases in SBP, and increases in PP, which were experienced earlier and to a greater degree in the female. Additionally, reduced antioxidant activity seen in newborns was worse in females in both the heart and skeletal muscle. These results suggest that in response to hyperoxia, newborn females are at a hemodynamic disadvantage when compared to males, which may be a contributing factor for why female children are at a higher risk during surgery or medical management involving hyperoxia.

Exposure to hyperoxia has been shown to have detrimental effects on newborn hemodynamics and antioxidant activities in males. These effects are unknown in the newborn female, despite clinical data showing that in children undergoing surgery females have poorer outcomes. This thesis explored whether newborn females respond worse than males to hyperoxia, specifically in hemodynamics and antioxidant activity. Hemodynamic results showed continual decreases in DBP and MAP, increases in HR, decreases in SBP, and increases in PP, which were experienced earlier and to a greater degree in the female. Additionally, reduced antioxidant activity seen in newborns was worse in females in both the heart and skeletal muscle. These results suggest that in response to hyperoxia, newborn females are at a hemodynamic disadvantage when compared to males, which may be a contributing factor for why female children are at a higher risk during surgery or medical management involving hyperoxia.