Indiana University-Purdue University Indianapolis (IUPUI) / The Indian summer monsoon (ISM) is the dominant hydrometeorological phenomenon that provides the majority of precipitation to southern Asia and southeastern Tibet specifically. Reliable projections of ISM rainfall are critical for water management and hinge on our understanding of the drivers of the monsoon system and how these drivers will be impacted by climate change. Because instrumental climate records are limited in space and time, natural climate archives are required to understand how the ISM varied in the past in response to changes in climatic boundary climate conditions. Lake sediments are high-resolution natural paleoclimate archive that are widely distributed across the Tibetan Plateau, making them useful for investigating long-term precipitation trends and their response to climatic boundary conditions. To investigate changes in monsoon intensity during the Holocene, three lakes were sampled along an east-west transect in southeastern Tibet: Galang Co, Nir’Pa Co, and Cuobu. Paleoclimate records from each lake were developed using isotopic (leaf wax hydrogen isotopes; δ2H), sedimentological, and geochemical proxies of precipitation and lake levels. Sediments were sampled at high temporal frequencies, with most proxies resolved at decadal scales, to capture multi-decadal to millennial-scale variability in monsoon intensity and local hydroclimate conditions. The ISM was strongest in the early Holocene as evidenced by leaf-wax n-alkane δ2H at both Cuobu and Galang Co corresponding with Cuobu’s higher lake levels and effective moisture. Monsoon intensity declined at Cuobu and Galang Co around 6 ka which corresponds to reduced riverine sediment influxes at Cuobu and deeper lake levels at Galang Co. The antiphase relationship between lake levels and monsoon intensity at Galang Co is attributed to air temperatures and effective moisture, with a warmer and drier local hydroclimate driving early Holocene low lake levels. The late Holocene ISM was more variable with wet and dry periods, as seen in the Nir’Pa Co lake level and leaf wax n-alkane δ2H record. These records demonstrate coherent drivers of synoptic and local hydroclimate that account for Holocene ISM expression across the southeastern Tibetan Plateau, indicating possible drivers of future monsoon expression under climate change.