No description available.

Includes bilbiographical references (24 leaves). / 1v. : ill. (chiefly col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Experiments suggest that Gastrulation and Brain specific Homeobox 2 is more likely to function providing positional information along the anterior-posterior embryonic axis than to control survival, proliferation, or differentiation of neural or hematopoietic progenitor cells. A model is presented which proposes that Gastrulation and Brain specific Homeobox 2, along with Otx2, is responsible for early definition of posterior and anterior regions of the developing embryonic axis, thereby establishing the midbrain-hindbrain organizer region. / Thesis (Ph.D.)--University of Adelaide, Dept. of Biochemistry, 2000

Thesis (Ph.D.)-- University of Adelaide, Dept. of Biochemistry, 2000. / Includes bilbiographical references (24 leaves).

Thesis (Ph. D.)--West Virginia University, 2003. / Title from document title page. Document formatted into pages; contains viii, 123 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 94-123).

published_or_final_version / Biochemistry / Doctoral / Doctor of Philosophy

published_or_final_version / abstract / Surgery / Doctoral / Doctor of Philosophy

published_or_final_version / Pathology / Master / Master of Medical Sciences

No description available.

In the past study, we used a human gastric stem cell clone, KMU-GI2, isolated from endoscopically biopsied gastric mucosa. As we maintained this KMU-GI2 cell clone, we also found a subclone with spontaneous transformation, named KMU-CSN. We found this KMU-CSN cell line showed homogenous epithelial morphology, cell pile-up appearance due to contact insensitivity, enhanced anchorage independence (from 1.7% of KMU-GI2 to 22% of KMU-CSN) and cell immortalization (CPDL >100). The high tumorigenic potential of this KMU-CS12 cell line has been endorsed by the finding of the tumor formation in nude mice. By spectral karyotyping and SNP GeneChip® Mapping 500K Assay, we found chromosomal abnormalities in chromosome 12, which were derived from duplication of 7p15.1~15.3 and 7p22.1~22.3. In normal cells, HOXA genes were found to localize in chromosome 7. In this KMU-CS12 cell line, an increased expression of HOXA4¡B5¡B7¡B9¡B13 genes was also shown, as compared with KMU-CSN. With these findings, we hypothesized that HOXA genes may play a role in gastric carcinogenesis. Therefore, we can check the prevalence of HOXA genes abnormalities in human gastric cancer patients.

Thesis (M. Med. Sc.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 52-57).